1-[5-O-(4-methoxytrityl)-3-O-Benzyl-2-deoxy-2-vinyl-β-D-ribo-pentofuranosyl]thymine

Base Information

Chemical Name:1-[5-O-(4-methoxytrityl)-3-O-Benzyl-2-deoxy-2-vinyl-β-D-ribo-pentofuranosyl]thymine
CAS No.:1426833-59-1
Molecular Formula:C₃₉H₃₈N₂O₆
Molecular Weight:630.741
Hs Code.:

Synonyms:1-[5-O-(4-methoxytrityl)-3-O-Benzyl-2-deoxy-2-vinyl-β-D-ribo-pentofuranosyl]thymine

Suppliers and Price of 1-[5-O-(4-methoxytrityl)-3-O-Benzyl-2-deoxy-2-vinyl-β-D-ribo-pentofuranosyl]thymine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[5-O-(4-methoxytrityl)-3-O-Benzyl-2-deoxy-2-vinyl-β-D-ribo-pentofuranosyl]thymine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-[5-O-(4-methoxytrityl)-3-O-Benzyl-2-deoxy-2-vinyl-β-D-ribo-pentofuranosyl]thymine

There total 6 articles about 1-[5-O-(4-methoxytrityl)-3-O-Benzyl-2-deoxy-2-vinyl-β-D-ribo-pentofuranosyl]thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 22423-26-3
O-2,2'-cyclo-5-methyluridine

: 1426833-59-1
1-[5-O-(4-methoxytrityl)-3-O-Benzyl-2-deoxy-2-vinyl-β-D-ribo-pentofuranosyl]thymine

Guidance literature:: Multi-step reaction with 5 steps

1.1: p-toluenesulfonic acid monohydrate; sodium iodide / acetone / 4 h / 55 °C

2.1: pyridine / 20 °C / Inert atmosphere

3.1: triethylamine; dmap / toluene / 1.17 h / 20 °C / Inert atmosphere

4.1: 2,2'-azobis(isobutyronitrile); hexamethyldistannane / benzene / 5 h / Reflux

4.2: 1 h / 20 °C

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / -10 °C / Inert atmosphere; Cooling with ice

5.2: 19 h / -10 - 4 °C

With pyridine; dmap; 2,2'-azobis(isobutyronitrile); p-toluenesulfonic acid monohydrate; hexamethyldistannane; sodium hydride; triethylamine; sodium iodide; In tetrahydrofuran; acetone; toluene; mineral oil; benzene;

Reference yield:

: 1426833-58-0
1-[5-O-(4-methoxytrityl)-2-deoxy-2-vinyl-β-D-ribo-pentofuranosyl]-thymine

: 100-39-0
benzyl bromide

: 1426833-59-1
1-[5-O-(4-methoxytrityl)-3-O-Benzyl-2-deoxy-2-vinyl-β-D-ribo-pentofuranosyl]thymine

Guidance literature:: 1-[5-O-(4-methoxytrityl)-2-deoxy-2-vinyl-β-D-ribo-pentofuranosyl]-thymine; With sodium hydride; In tetrahydrofuran; mineral oil; at -10 ℃; for 0.5h; Inert atmosphere; Cooling with ice;

benzyl bromide; In tetrahydrofuran; at -10 - 4 ℃; for 19h;

Reference yield:

: 1426833-54-6
1-[5-O-(4-methoxytrityl)-2-deoxy-2-iodo-β-D-ribofuranosyl] 5-methyluracil

: 1426833-59-1
1-[5-O-(4-methoxytrityl)-3-O-Benzyl-2-deoxy-2-vinyl-β-D-ribo-pentofuranosyl]thymine

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; dmap / toluene / 1.17 h / 20 °C / Inert atmosphere

2.1: 2,2'-azobis(isobutyronitrile); hexamethyldistannane / benzene / 5 h / Reflux

2.2: 1 h / 20 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / -10 °C / Inert atmosphere; Cooling with ice

3.2: 19 h / -10 - 4 °C

With dmap; 2,2'-azobis(isobutyronitrile); hexamethyldistannane; sodium hydride; triethylamine; In tetrahydrofuran; toluene; mineral oil; benzene;