N-(2,4-dimethoxybenzyl)-N-(6-fluoropyridin-2-yl)-2-oxo-2,3-dihydrobenzo[d]oxazole-6-sulfonamide

Base Information

Chemical Name:N-(2,4-dimethoxybenzyl)-N-(6-fluoropyridin-2-yl)-2-oxo-2,3-dihydrobenzo[d]oxazole-6-sulfonamide
CAS No.:1607485-75-5
Molecular Formula:C₂₁H₁₈FN₃O₆S
Molecular Weight:459.455
Hs Code.:

Synonyms:N-(2,4-dimethoxybenzyl)-N-(6-fluoropyridin-2-yl)-2-oxo-2,3-dihydrobenzo[d]oxazole-6-sulfonamide

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Chemical Property of N-(2,4-dimethoxybenzyl)-N-(6-fluoropyridin-2-yl)-2-oxo-2,3-dihydrobenzo[d]oxazole-6-sulfonamide

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Technology Process of N-(2,4-dimethoxybenzyl)-N-(6-fluoropyridin-2-yl)-2-oxo-2,3-dihydrobenzo[d]oxazole-6-sulfonamide

There total 4 articles about N-(2,4-dimethoxybenzyl)-N-(6-fluoropyridin-2-yl)-2-oxo-2,3-dihydrobenzo[d]oxazole-6-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 27685-90-1
2-oxo-2,3-dihydrobenzo[d]oxazole-6-sulfonyl chloride

: 1275088-21-5
N-(2,4-dimethoxybenzyl)-6-fluoropyridin-2-amine

: 1607485-75-5
N-(2,4-dimethoxybenzyl)-N-(6-fluoropyridin-2-yl)-2-oxo-2,3-dihydrobenzo[d]oxazole-6-sulfonamide

Guidance literature:: N-(2,4-dimethoxybenzyl)-6-fluoropyridin-2-amine; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 20 ℃; for 0.666667h; Inert atmosphere;

2-oxo-2,3-dihydrobenzo[d]oxazole-6-sulfonyl chloride; In tetrahydrofuran; at -78 - 20 ℃; for 0.666667h; Inert atmosphere;

Reference yield:

: 1597-32-6
6-fluoro-pyridin-2-ylamine

: 1607485-75-5
N-(2,4-dimethoxybenzyl)-N-(6-fluoropyridin-2-yl)-2-oxo-2,3-dihydrobenzo[d]oxazole-6-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / toluene / 135 °C

2.1: sodium tetrahydroborate / tetrahydrofuran / 2.5 h / 0 °C / Sealed tube

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.67 h / -78 - 20 °C / Inert atmosphere

3.2: 0.67 h / -78 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; toluene;

Reference yield:

: 1607485-74-4
N-(2,4-dimethoxybenzylidene)-6-fluoropyridin-2-amine

: 1607485-75-5
N-(2,4-dimethoxybenzyl)-N-(6-fluoropyridin-2-yl)-2-oxo-2,3-dihydrobenzo[d]oxazole-6-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / tetrahydrofuran / 2.5 h / 0 °C / Sealed tube

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.67 h / -78 - 20 °C / Inert atmosphere

2.2: 0.67 h / -78 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; lithium hexamethyldisilazane; In tetrahydrofuran;