N-[3-(trityl-amino)-propyl]-N-{4-[3-(trityl-amino)-propylamino]-butyl}-succinamic acid

Base Information

• Chemical Name: N-[3-(trityl-amino)-propyl]-N-{4-[3-(trityl-amino)-propylamino]-butyl}-succinamic acid
• CAS No.: 450408-95-4
• Molecular Formula: C₅₂H₅₈N₄O₃
• Molecular Weight: 787.058
• Mol file: 450408-95-4.mol

Synonyms:N-[3-(trityl-amino)-propyl]-N-{4-[3-(trityl-amino)-propylamino]-butyl}-succinamic acid

Chemical Property of N-[3-(trityl-amino)-propyl]-N-{4-[3-(trityl-amino)-propylamino]-butyl}-succinamic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[3-(trityl-amino)-propyl]-N-{4-[3-(trityl-amino)-propylamino]-butyl}-succinamic acid

There total 1 articles about N-[3-(trityl-amino)-propyl]-N-{4-[3-(trityl-amino)-propylamino]-butyl}-succinamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

succinic acid anhydride (108-30-5) + N1,N14-bis(triphenylmethyl)spermine (168699-01-2) → N-[3-(trityl-amino)-propyl]-N-{4-[3-(trityl-amino)-propylamino]-butyl}-succinamic acid (450408-95-4) + N-(4-{(3-carboxy-propionyl)-[3-(trityl-amino)-propyl]-amino}-butyl)-N-[3-(trityl-amino)-propyl]-succinamic acid

Guidance literature:

In dichloromethane; at 0 - 25 ℃; for 26h;

DOI:10.1016/S0040-4039(02)00335-0

Reference yield: 57.0%

N-[3-(trityl-amino)-propyl]-N-{4-[3-(trityl-amino)-propylamino]-butyl}-succinamic acid (450408-95-4) → 1,6-bis-[3-(trityl-amino)-propyl]-[1,6]diazecane-2,5-dione (450408-96-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In chloroform; at 25 ℃; for 48h;

DOI:10.1016/S0040-4039(02)00335-0

Reference yield:

N-[3-(trityl-amino)-propyl]-N-{4-[3-(trityl-amino)-propylamino]-butyl}-succinamic acid (450408-95-4) → (E)-3-(3,4-Dihydroxy-phenyl)-N-[3-(6-{3-[(E)-3-(3,4-dihydroxy-phenyl)-acryloylamino]-propyl}-[1,6]diazecan-1-yl)-propyl]-acrylamide

Guidance literature:

Multi-step reaction with 5 steps

1: 57 percent / bromotripyrrolidinophosphonium hexafluorophosphate; iPr₂NEt / CHCl₃ / 48 h / 25 °C

2: 78 percent / LiAlH₄ / tetrahydrofuran / 5 h / Heating

3: TFA / CH₂Cl₂ / 0.5 h / 25 °C

4: 47 percent / Et₃N / dimethylformamide / 24.5 h / 0 - 25 °C

5: 89 percent / H₂; aq. HCl / Pd/C / acetic acid; methanol; H₂O / 4 h / 25 °C

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; chloroform; water; acetic acid; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(02)00335-0

upstream raw materials:

succinic acid anhydride

N¹,N¹⁴-bis(triphenylmethyl)spermine

Downstream raw materials:

1,6-bis-[3-(trityl-amino)-propyl]-[1,6]diazecane-2,5-dione

trityl-(3-{6-[3-(trityl-amino)-propyl]-[1,6]diazecan-1-yl}-propyl)-amine

(E)-3-(3,4-Bis-benzyloxy-phenyl)-N-[3-(6-{3-[(E)-3-(3,4-bis-benzyloxy-phenyl)-acryloylamino]-propyl}-[1,6]diazecan-1-yl)-propyl]-acrylamide