4-oxo-4-(4-(quinazolin-4-ylamino)phenylamino)butanoic acid

Base Information

• Chemical Name: 4-oxo-4-(4-(quinazolin-4-ylamino)phenylamino)butanoic acid
• CAS No.: 1630954-12-9
• Molecular Formula: C₁₈H₁₆N₄O₃
• Molecular Weight: 336.35
• Mol file: 1630954-12-9.mol

Synonyms:4-oxo-4-(4-(quinazolin-4-ylamino)phenylamino)butanoic acid

Chemical Property of 4-oxo-4-(4-(quinazolin-4-ylamino)phenylamino)butanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-oxo-4-(4-(quinazolin-4-ylamino)phenylamino)butanoic acid

There total 4 articles about 4-oxo-4-(4-(quinazolin-4-ylamino)phenylamino)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

succinic acid anhydride (108-30-5) + 4-(4-aminoanilino)quinazoline (34932-33-7) → 4-oxo-4-(4-(quinazolin-4-ylamino)phenylamino)butanoic acid (1630954-12-9)

Guidance literature:

In 1,4-dioxane; for 5h; Reflux;

DOI:10.1248/cpb.c14-00016

Reference yield:

anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) → 4-oxo-4-(4-(quinazolin-4-ylamino)phenylamino)butanoic acid (1630954-12-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 120 - 140 °C

2.1: trichlorophosphate / N,N-dimethyl-formamide / 100 - 105 °C

2.2: Cooling with ice

3.1: chloroform / 0.5 h / Cooling with ice

3.2: 24 h / 20 °C

4.1: 1,4-dioxane / 5 h / Reflux

With trichlorophosphate; In 1,4-dioxane; chloroform; N,N-dimethyl-formamide;

DOI:10.1248/cpb.c14-00016

Reference yield:

4-Hydroxyquinazoline (491-36-1) → 4-oxo-4-(4-(quinazolin-4-ylamino)phenylamino)butanoic acid (1630954-12-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: trichlorophosphate / N,N-dimethyl-formamide / 100 - 105 °C

1.2: Cooling with ice

2.1: chloroform / 0.5 h / Cooling with ice

2.2: 24 h / 20 °C

3.1: 1,4-dioxane / 5 h / Reflux

With trichlorophosphate; In 1,4-dioxane; chloroform; N,N-dimethyl-formamide;

DOI:10.1248/cpb.c14-00016

upstream raw materials:

anthranilic acid

4-Hydroxyquinazoline

succinic acid anhydride

4-(4-aminoanilino)quinazoline