N-[(S)-5-Benzyloxy-1-[(E)-2-((1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-vinyl]-1-(3-triisopropylsilanyloxy-propyl)-pentyl]-acrylamide

Base Information

Chemical Name:N-[(S)-5-Benzyloxy-1-[(E)-2-((1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-vinyl]-1-(3-triisopropylsilanyloxy-propyl)-pentyl]-acrylamide
CAS No.:920749-86-6
Molecular Formula:C₃₉H₆₇NO₃Si
Molecular Weight:626.051
Hs Code.:

Synonyms:N-[(S)-5-Benzyloxy-1-[(E)-2-((1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-vinyl]-1-(3-triisopropylsilanyloxy-propyl)-pentyl]-acrylamide

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Chemical Property of N-[(S)-5-Benzyloxy-1-[(E)-2-((1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-vinyl]-1-(3-triisopropylsilanyloxy-propyl)-pentyl]-acrylamide

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Technology Process of N-[(S)-5-Benzyloxy-1-[(E)-2-((1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-vinyl]-1-(3-triisopropylsilanyloxy-propyl)-pentyl]-acrylamide

There total 4 articles about N-[(S)-5-Benzyloxy-1-[(E)-2-((1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-vinyl]-1-(3-triisopropylsilanyloxy-propyl)-pentyl]-acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 920749-75-3
{(S)-8-Benzyloxy-4-isocyanato-4-[(E)-2-((1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-vinyl]-octyloxy}-triisopropyl-silane

: 1826-67-1
vinyl magnesium bromide

: 920749-86-6
N-[(S)-5-Benzyloxy-1-[(E)-2-((1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-vinyl]-1-(3-triisopropylsilanyloxy-propyl)-pentyl]-acrylamide

Guidance literature:: In tetrahydrofuran; at 0 ℃; for 2h;
DOI:10.1016/j.jorganchem.2006.07.028

Reference yield:

: {8-Benzyloxy-4-[1-iodo-meth-(Z)-ylidene]-octyloxy}-triisopropyl-silane

: 920749-86-6
N-[(S)-5-Benzyloxy-1-[(E)-2-((1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-vinyl]-1-(3-triisopropylsilanyloxy-propyl)-pentyl]-acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / diethyl ether; petroleum ether / 1 h / -78 - 20 °C

1.2: 97 percent / AlMe₃ / diethyl ether; petroleum ether / -78 - 20 °C

2.1: CH₂Cl₂ / 1 h / 0 °C

2.2: potassium carbonate / methanol; H₂O / 0 - 20 °C

2.3: 99 percent / TFAA; triethylamine / CH₂Cl₂ / 0.25 h / 0 °C

3.1: 65 percent / tetrahydrofuran / 2 h / 0 °C

With n-butyllithium; In tetrahydrofuran; diethyl ether; dichloromethane; Petroleum ether;
DOI:10.1016/j.jorganchem.2006.07.028

Reference yield:

: 80434-59-9,485843-44-5,796865-68-4
(1R,2S,5R)-2-isopropyl-5-methylcyclohexanecarboxaldehyde

: 920749-86-6
N-[(S)-5-Benzyloxy-1-[(E)-2-((1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-vinyl]-1-(3-triisopropylsilanyloxy-propyl)-pentyl]-acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / diethyl ether; petroleum ether / 1 h / -78 - 20 °C

1.2: 97 percent / AlMe₃ / diethyl ether; petroleum ether / -78 - 20 °C

2.1: CH₂Cl₂ / 1 h / 0 °C

2.2: potassium carbonate / methanol; H₂O / 0 - 20 °C

2.3: 99 percent / TFAA; triethylamine / CH₂Cl₂ / 0.25 h / 0 °C

3.1: 65 percent / tetrahydrofuran / 2 h / 0 °C

With n-butyllithium; In tetrahydrofuran; diethyl ether; dichloromethane; Petroleum ether;
DOI:10.1016/j.jorganchem.2006.07.028