{(S)-8-Benzyloxy-4-isocyanato-4-[(E)-2-((1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-vinyl]-octyloxy}-triisopropyl-silane

Base Information

Chemical Name:{(S)-8-Benzyloxy-4-isocyanato-4-[(E)-2-((1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-vinyl]-octyloxy}-triisopropyl-silane
CAS No.:920749-75-3
Molecular Formula:C₃₇H₆₃NO₃Si
Molecular Weight:597.998
Hs Code.:

Synonyms:{(S)-8-Benzyloxy-4-isocyanato-4-[(E)-2-((1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-vinyl]-octyloxy}-triisopropyl-silane

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Chemical Property of {(S)-8-Benzyloxy-4-isocyanato-4-[(E)-2-((1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-vinyl]-octyloxy}-triisopropyl-silane

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Technology Process of {(S)-8-Benzyloxy-4-isocyanato-4-[(E)-2-((1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-vinyl]-octyloxy}-triisopropyl-silane

There total 3 articles about {(S)-8-Benzyloxy-4-isocyanato-4-[(E)-2-((1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-vinyl]-octyloxy}-triisopropyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 920749-68-4
(Z)-(S)-7-Benzyloxy-1-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-3-(3-triisopropylsilanyloxy-propyl)-hept-2-en-1-ol

: 3019-71-4
Trichloroacetyl isocyanate

: 920749-75-3
{(S)-8-Benzyloxy-4-isocyanato-4-[(E)-2-((1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-vinyl]-octyloxy}-triisopropyl-silane

Guidance literature:: (Z)-(S)-7-Benzyloxy-1-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-3-(3-triisopropylsilanyloxy-propyl)-hept-2-en-1-ol; Trichloroacetyl isocyanate; In dichloromethane; at 0 ℃; for 1h;

With potassium carbonate; In methanol; water; at 0 - 20 ℃;

With triethylamine; trifluoroacetic anhydride; In dichloromethane; at 0 ℃; for 0.25h;
DOI:10.1016/j.jorganchem.2006.07.028

Reference yield:

: {8-Benzyloxy-4-[1-iodo-meth-(Z)-ylidene]-octyloxy}-triisopropyl-silane

: 920749-75-3
{(S)-8-Benzyloxy-4-isocyanato-4-[(E)-2-((1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-vinyl]-octyloxy}-triisopropyl-silane

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / diethyl ether; petroleum ether / 1 h / -78 - 20 °C

1.2: 97 percent / AlMe₃ / diethyl ether; petroleum ether / -78 - 20 °C

2.1: CH₂Cl₂ / 1 h / 0 °C

2.2: potassium carbonate / methanol; H₂O / 0 - 20 °C

2.3: 99 percent / TFAA; triethylamine / CH₂Cl₂ / 0.25 h / 0 °C

With n-butyllithium; In diethyl ether; dichloromethane; Petroleum ether;
DOI:10.1016/j.jorganchem.2006.07.028

Reference yield:

: 80434-59-9,485843-44-5,796865-68-4
(1R,2S,5R)-2-isopropyl-5-methylcyclohexanecarboxaldehyde

: 920749-75-3
{(S)-8-Benzyloxy-4-isocyanato-4-[(E)-2-((1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-vinyl]-octyloxy}-triisopropyl-silane

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / diethyl ether; petroleum ether / 1 h / -78 - 20 °C

1.2: 97 percent / AlMe₃ / diethyl ether; petroleum ether / -78 - 20 °C

2.1: CH₂Cl₂ / 1 h / 0 °C

2.2: potassium carbonate / methanol; H₂O / 0 - 20 °C

2.3: 99 percent / TFAA; triethylamine / CH₂Cl₂ / 0.25 h / 0 °C

With n-butyllithium; In diethyl ether; dichloromethane; Petroleum ether;
DOI:10.1016/j.jorganchem.2006.07.028