N-methoxy-3-(4'-methoxyphenyl)-N-methyl-4-phenyl-1H-pyrrole-2-carboxamide

Base Information

Chemical Name:N-methoxy-3-(4'-methoxyphenyl)-N-methyl-4-phenyl-1H-pyrrole-2-carboxamide
CAS No.:1337927-73-7
Molecular Formula:C₂₀H₂₀N₂O₃
Molecular Weight:336.39
Hs Code.:

Synonyms:N-methoxy-3-(4'-methoxyphenyl)-N-methyl-4-phenyl-1H-pyrrole-2-carboxamide

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Chemical Property of N-methoxy-3-(4'-methoxyphenyl)-N-methyl-4-phenyl-1H-pyrrole-2-carboxamide

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Technology Process of N-methoxy-3-(4'-methoxyphenyl)-N-methyl-4-phenyl-1H-pyrrole-2-carboxamide

There total 9 articles about N-methoxy-3-(4'-methoxyphenyl)-N-methyl-4-phenyl-1H-pyrrole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 37629-90-6
(E)-2-(4'-methoxyphenyl)-1-nitro-1-phenylethene

: 163625-26-1
2-isocyano-N-methoxy-N-methylacetamide

: 1337927-73-7
N-methoxy-3-(4'-methoxyphenyl)-N-methyl-4-phenyl-1H-pyrrole-2-carboxamide

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; isopropyl alcohol; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/jo2013516

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 1337927-73-7
N-methoxy-3-(4'-methoxyphenyl)-N-methyl-4-phenyl-1H-pyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / methanol / 1 h / 5 °C / Inert atmosphere

2: pyridine; bromine / cyclohexane / Inert atmosphere; Reflux

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; water / 20 °C / Inert atmosphere; Reflux

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran; isopropyl alcohol / 0 - 20 °C / Inert atmosphere

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; In tetrahydrofuran; methanol; cyclohexane; water; isopropyl alcohol; 1: Henry reaction / 3: Suzuki-Miyaura coupling / 4: Barton-Zard pyrrole reaction;
DOI:10.1021/jo2013516

Reference yield:

: 622-42-4
1-nitro-1-phenylmethane

: 1337927-73-7
N-methoxy-3-(4'-methoxyphenyl)-N-methyl-4-phenyl-1H-pyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / methanol / 2.5 h / 20 °C / Inert atmosphere

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran; isopropyl alcohol / 0 - 20 °C / Inert atmosphere

With acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; methanol; isopropyl alcohol; 1: modified Henry reaction / 2: Barton-Zard pyrrole reaction;
DOI:10.1021/jo2013516