1,7,9-triazabicyclo[4.3.0]nona-2,4,6,8-tetraene

Base Information

• Chemical Name: 1,7,9-triazabicyclo[4.3.0]nona-2,4,6,8-tetraene
• CAS No.: 274-85-1
• Molecular Formula: C6H5 N3
• Molecular Weight: 119.12
• Hs Code.: 2933990090
• Mol file: 274-85-1.mol

Synonyms:s-Triazolo[1,5-a]pyridine(7CI,8CI); 1,3,3a-Triazaindene; 1,3-Diazaindolizine; NSC 99874

Chemical Property of 1,7,9-triazabicyclo[4.3.0]nona-2,4,6,8-tetraene

Chemical Property:

• Melting Point: 110-112 °C
• Boiling Point: °Cat760mmHg
• PKA: 2.70±0.30(Predicted)
• Flash Point: °C
• PSA: 30.19000
• Density: 1.29g/cm³
• LogP: 0.72930

Purity/Quality:

97% ^*data from raw suppliers

[1,2,4]Triazolo[1,5-a]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: [1,2,4]Triazolo[1,5-a]pyridine (cas# 274-85-1) is a useful reactant in the synthesis of 1,?2,?4-?triazolo[4,?3-?a]?quinolines.

Technology Process of 1,7,9-triazabicyclo[4.3.0]nona-2,4,6,8-tetraene

There total 9 articles about 1,7,9-triazabicyclo[4.3.0]nona-2,4,6,8-tetraene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

N'-hydroxy-N-(pyridin-2-yl)formimidamide (69512-30-7) → s-triazolo(1,5-a)pyridine (274-85-1)

Guidance literature:

With trifluoroacetic anhydride; In tetrahydrofuran; at 20 ℃;

DOI:10.1002/ejoc.200500247

Reference yield: 48.0%

formic acid (64-18-6) + 1-amino-2-hydroxyimino-1,2-dihydropyridine (72647-21-3) → s-triazolo(1,5-a)pyridine (274-85-1)

Guidance literature:

at 196 ℃;

DOI:10.1016/S0040-4020(01)98945-8

Reference yield: 34.0%

ethyl N-(pyridin-2-yl)formimidate (33842-49-8) → N-(pyridin-2-yl)cyanamide (21418-21-3) + s-triazolo(1,5-a)pyridine (274-85-1)

Guidance literature:

With hydroxylamine-O-sulfonic acid; In pyridine; methanol; for 1h; Ambient temperature;

DOI:10.1021/jo00328a028

upstream raw materials:

formic acid

1-amino-2-hydroxyimino-1,2-dihydropyridine

N'-hydroxy-N-(pyridin-2-yl)formimidamide

ethyl N-(pyridin-2-yl)formimidate

Downstream raw materials:

5-bromo<1,2,4>triazolo<1,5-a>pyridine

α-<3-(trifluoromethyl)phenyl><1,2,4>triazolo<1,5-a>pyridine-5-methanol

[1,2,4]triazolo[1,5-a]pyridine-5-carbaldehyde

5-methyl[1,2,4]triazolo[1,5-a]pyridine