8-carboethoxymethoxy-5-<3-(N-benzyloxycarbonyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-3,4-dihydrocarbostyril

Base Information

Chemical Name:8-carboethoxymethoxy-5-<3-(N-benzyloxycarbonyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-3,4-dihydrocarbostyril
CAS No.:80090-29-5
Molecular Formula:C₃₄H₄₀N₂O₁₀
Molecular Weight:636.699
Hs Code.:

Synonyms:8-carboethoxymethoxy-5-<3-(N-benzyloxycarbonyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-3,4-dihydrocarbostyril

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Chemical Property of 8-carboethoxymethoxy-5-<3-(N-benzyloxycarbonyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-3,4-dihydrocarbostyril

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Technology Process of 8-carboethoxymethoxy-5-<3-(N-benzyloxycarbonyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-3,4-dihydrocarbostyril

There total 8 articles about 8-carboethoxymethoxy-5-<3-(N-benzyloxycarbonyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-3,4-dihydrocarbostyril which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.8%

: 105-36-2
ethyl bromoacetate

: 73642-17-8
5-<3-(N-benzyloxycarbonyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-8-hydroxy-3,4-dihydrocarbostyril

: 80090-29-5
8-carboethoxymethoxy-5-<3-(N-benzyloxycarbonyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-3,4-dihydrocarbostyril

Guidance literature:: With potassium carbonate; In water; acetone; for 9h; Ambient temperature;
DOI:10.1248/cpb.29.2166

Reference yield:

: 59430-56-7
5,8-Dihydroxy-3,4-dihydro-2(1H)-quinolinone

: 80090-29-5
8-carboethoxymethoxy-5-<3-(N-benzyloxycarbonyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-3,4-dihydrocarbostyril

Guidance literature:: Multi-step reaction with 7 steps

1: 48 percent / K₂CO₃ / acetone; H₂O / 4 h / Heating

2: 56 percent / K₂CO₃ / propan-2-ol / 5 h / 70 - 80 °C

3: 43.6 percent / methanol / 20 h / Ambient temperature

4: 77.2 percent / hydrogen / 10percent Pd-C / methanol; H₂O / 8 h / Ambient temperature

5: 96 percent / 10percent Na₂CO₃, NaOH / acetone; H₂O / 1.5 h / Ambient temperature

6: 100 percent / 2N NaOH / methanol / Ambient temperature

7: 73.8 percent / K₂CO₃ / acetone; H₂O / 9 h / Ambient temperature

With sodium hydroxide; hydrogen; sodium carbonate; potassium carbonate; palladium on activated charcoal; In methanol; water; isopropyl alcohol; acetone;
DOI:10.1248/cpb.29.2166

Reference yield:

: 59826-16-3
8-(Benzyloxy)-5-hydroxy-3,4-dihydro-2(1H)-quinolinone

: 80090-29-5
8-carboethoxymethoxy-5-<3-(N-benzyloxycarbonyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-3,4-dihydrocarbostyril

Guidance literature:: Multi-step reaction with 6 steps

1: 56 percent / K₂CO₃ / propan-2-ol / 5 h / 70 - 80 °C

2: 43.6 percent / methanol / 20 h / Ambient temperature

3: 77.2 percent / hydrogen / 10percent Pd-C / methanol; H₂O / 8 h / Ambient temperature

4: 96 percent / 10percent Na₂CO₃, NaOH / acetone; H₂O / 1.5 h / Ambient temperature

5: 100 percent / 2N NaOH / methanol / Ambient temperature

6: 73.8 percent / K₂CO₃ / acetone; H₂O / 9 h / Ambient temperature

With sodium hydroxide; hydrogen; sodium carbonate; potassium carbonate; palladium on activated charcoal; In methanol; water; isopropyl alcohol; acetone;
DOI:10.1248/cpb.29.2166