(R)-6-(5-bromo-2-fluoro-phenyl)-3-fluoro-6-methyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazine-4-thione

Base Information

Chemical Name:(R)-6-(5-bromo-2-fluoro-phenyl)-3-fluoro-6-methyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazine-4-thione
CAS No.:1397683-57-6
Molecular Formula:C₁₃H₁₀BrF₂N₃S
Molecular Weight:358.209
Hs Code.:

Synonyms:(R)-6-(5-bromo-2-fluoro-phenyl)-3-fluoro-6-methyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazine-4-thione

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Chemical Property of (R)-6-(5-bromo-2-fluoro-phenyl)-3-fluoro-6-methyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazine-4-thione

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Technology Process of (R)-6-(5-bromo-2-fluoro-phenyl)-3-fluoro-6-methyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazine-4-thione

There total 1 articles about (R)-6-(5-bromo-2-fluoro-phenyl)-3-fluoro-6-methyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazine-4-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1397683-57-6
(R)-6-(5-bromo-2-fluoro-phenyl)-3-fluoro-6-methyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazine-4-thione

Guidance literature:

Reference yield: 83.0%

: 1397683-57-6
(R)-6-(5-bromo-2-fluoro-phenyl)-3-fluoro-6-methyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazine-4-thione

: 1397683-58-7
(R)-6-(5-bromo-2-fluoro-phenyl)-3-fluoro-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine

Guidance literature:: With ammonia; In methanol; water; at 20 - 100 ℃; for 6h; Sealed tube;

Reference yield:

: 1397683-57-6
(R)-6-(5-bromo-2-fluoro-phenyl)-3-fluoro-6-methyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazine-4-thione

: 1397683-16-7
(R)-5-methoxy-pyrazine-2-carboxylic acid[3-(4-amino-3-fluoro-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-4-fluoro-phenyl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonia / water; methanol / 6 h / 20 - 100 °C / Sealed tube

2.1: potassium tert-butylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 18 h / 20 - 90 °C / Sealed tube; Inert atmosphere

3.1: hydrogenchloride / isopropyl alcohol / 2 h / 20 °C

3.2: 1 h

4.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / methanol / 0.08 h / 20 °C

4.2: 4 h / 0 - 20 °C

With hydrogenchloride; potassium tert-butylate; ammonia; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In methanol; water; isopropyl alcohol; toluene;