(R)-6-(5-amino-2-fluoro-phenyl)-3-fluoro-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine

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Chemical Name:(R)-6-(5-amino-2-fluoro-phenyl)-3-fluoro-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine
CAS No.:1397683-60-1
Molecular Formula:C₁₃H₁₃F₂N₅
Molecular Weight:277.277
Hs Code.:

Synonyms:(R)-6-(5-amino-2-fluoro-phenyl)-3-fluoro-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine

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Chemical Property of (R)-6-(5-amino-2-fluoro-phenyl)-3-fluoro-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine

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Technology Process of (R)-6-(5-amino-2-fluoro-phenyl)-3-fluoro-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine

There total 3 articles about (R)-6-(5-amino-2-fluoro-phenyl)-3-fluoro-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1397683-59-8
(R)-6-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-3-fluoro-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine

: 1397683-60-1
(R)-6-(5-amino-2-fluoro-phenyl)-3-fluoro-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine

Guidance literature:: (R)-6-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-3-fluoro-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine; With hydrogenchloride; In isopropyl alcohol; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In isopropyl alcohol; for 1h;

Reference yield:

: 1397683-57-6
(R)-6-(5-bromo-2-fluoro-phenyl)-3-fluoro-6-methyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazine-4-thione

: 1397683-60-1
(R)-6-(5-amino-2-fluoro-phenyl)-3-fluoro-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonia / water; methanol / 6 h / 20 - 100 °C / Sealed tube

2.1: potassium tert-butylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 18 h / 20 - 90 °C / Sealed tube; Inert atmosphere

3.1: hydrogenchloride / isopropyl alcohol / 2 h / 20 °C

3.2: 1 h

With hydrogenchloride; potassium tert-butylate; ammonia; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In methanol; water; isopropyl alcohol; toluene;

Reference yield:

: 1397683-58-7
(R)-6-(5-bromo-2-fluoro-phenyl)-3-fluoro-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine

: 1397683-60-1
(R)-6-(5-amino-2-fluoro-phenyl)-3-fluoro-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 18 h / 20 - 90 °C / Sealed tube; Inert atmosphere

2.1: hydrogenchloride / isopropyl alcohol / 2 h / 20 °C

2.2: 1 h

With hydrogenchloride; potassium tert-butylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In isopropyl alcohol; toluene;