(R)-6-(5-bromo-2-fluoro-phenyl)-3-fluoro-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine

Base Information

Chemical Name:(R)-6-(5-bromo-2-fluoro-phenyl)-3-fluoro-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine
CAS No.:1397683-58-7
Molecular Formula:C₁₃H₁₁BrF₂N₄
Molecular Weight:341.158
Hs Code.:

Synonyms:(R)-6-(5-bromo-2-fluoro-phenyl)-3-fluoro-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine

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Chemical Property of (R)-6-(5-bromo-2-fluoro-phenyl)-3-fluoro-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine

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Technology Process of (R)-6-(5-bromo-2-fluoro-phenyl)-3-fluoro-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine

There total 1 articles about (R)-6-(5-bromo-2-fluoro-phenyl)-3-fluoro-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1397683-57-6
(R)-6-(5-bromo-2-fluoro-phenyl)-3-fluoro-6-methyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazine-4-thione

: 1397683-58-7
(R)-6-(5-bromo-2-fluoro-phenyl)-3-fluoro-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine

Guidance literature:: With ammonia; In methanol; water; at 20 - 100 ℃; for 6h; Sealed tube;

Reference yield: 83.0%

: benzophenoneimine

: 1397683-58-7
(R)-6-(5-bromo-2-fluoro-phenyl)-3-fluoro-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine

: 1397683-59-8
(R)-6-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-3-fluoro-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine

Guidance literature:: With potassium tert-butylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In toluene; at 20 - 90 ℃; for 18h; Sealed tube; Inert atmosphere;

Reference yield:

: 1397683-58-7
(R)-6-(5-bromo-2-fluoro-phenyl)-3-fluoro-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine

: 1397683-16-7
(R)-5-methoxy-pyrazine-2-carboxylic acid[3-(4-amino-3-fluoro-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-4-fluoro-phenyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 18 h / 20 - 90 °C / Sealed tube; Inert atmosphere

2.1: hydrogenchloride / isopropyl alcohol / 2 h / 20 °C

2.2: 1 h

3.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / methanol / 0.08 h / 20 °C

3.2: 4 h / 0 - 20 °C

With hydrogenchloride; potassium tert-butylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In methanol; isopropyl alcohol; toluene;