(R)-5-methoxy-pyrazine-2-carboxylic acid[3-(4-amino-3-fluoro-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-4-fluoro-phenyl]-amide

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Chemical Name:(R)-5-methoxy-pyrazine-2-carboxylic acid[3-(4-amino-3-fluoro-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-4-fluoro-phenyl]-amide
CAS No.:1397683-16-7
Molecular Formula:C₁₉H₁₇F₂N₇O₂
Molecular Weight:413.386
Hs Code.:

Synonyms:(R)-5-methoxy-pyrazine-2-carboxylic acid[3-(4-amino-3-fluoro-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-4-fluoro-phenyl]-amide

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Chemical Property of (R)-5-methoxy-pyrazine-2-carboxylic acid[3-(4-amino-3-fluoro-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-4-fluoro-phenyl]-amide

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Technology Process of (R)-5-methoxy-pyrazine-2-carboxylic acid[3-(4-amino-3-fluoro-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-4-fluoro-phenyl]-amide

There total 4 articles about (R)-5-methoxy-pyrazine-2-carboxylic acid[3-(4-amino-3-fluoro-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-4-fluoro-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1397683-60-1
(R)-6-(5-amino-2-fluoro-phenyl)-3-fluoro-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine

: 40155-42-8
5-methoxy-pyrazine-2-carboxylic acid

: 1397683-16-7
(R)-5-methoxy-pyrazine-2-carboxylic acid[3-(4-amino-3-fluoro-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-4-fluoro-phenyl]-amide

Guidance literature:: 5-methoxy-pyrazine-2-carboxylic acid; With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In methanol; at 20 ℃; for 0.0833333h;

(R)-6-(5-amino-2-fluoro-phenyl)-3-fluoro-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine; In methanol; at 0 - 20 ℃; for 4h;

With sodium carbonate; In methanol; water;

Reference yield:

: 1397683-57-6
(R)-6-(5-bromo-2-fluoro-phenyl)-3-fluoro-6-methyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazine-4-thione

: 1397683-16-7
(R)-5-methoxy-pyrazine-2-carboxylic acid[3-(4-amino-3-fluoro-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-4-fluoro-phenyl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonia / water; methanol / 6 h / 20 - 100 °C / Sealed tube

2.1: potassium tert-butylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 18 h / 20 - 90 °C / Sealed tube; Inert atmosphere

3.1: hydrogenchloride / isopropyl alcohol / 2 h / 20 °C

3.2: 1 h

4.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / methanol / 0.08 h / 20 °C

4.2: 4 h / 0 - 20 °C

With hydrogenchloride; potassium tert-butylate; ammonia; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In methanol; water; isopropyl alcohol; toluene;

Reference yield:

: 1397683-58-7
(R)-6-(5-bromo-2-fluoro-phenyl)-3-fluoro-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine

: 1397683-16-7
(R)-5-methoxy-pyrazine-2-carboxylic acid[3-(4-amino-3-fluoro-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-4-fluoro-phenyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 18 h / 20 - 90 °C / Sealed tube; Inert atmosphere

2.1: hydrogenchloride / isopropyl alcohol / 2 h / 20 °C

2.2: 1 h

3.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / methanol / 0.08 h / 20 °C

3.2: 4 h / 0 - 20 °C

With hydrogenchloride; potassium tert-butylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In methanol; isopropyl alcohol; toluene;