2-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)-N'-hydroxyacetimidamide

Base Information

• Chemical Name: 2-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)-N'-hydroxyacetimidamide
• CAS No.: 1197849-54-9
• Molecular Formula: C₁₅H₁₃ClN₄O
• Molecular Weight: 300.747
• Mol file: 1197849-54-9.mol

Synonyms:2-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)-N'-hydroxyacetimidamide

Chemical Property of 2-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)-N'-hydroxyacetimidamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)-N'-hydroxyacetimidamide

There total 2 articles about 2-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)-N'-hydroxyacetimidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.4%

2-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)acetonitrile (17744-99-9) → 2-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)-N'-hydroxyacetimidamide (1197849-54-9)

Guidance literature:

With hydroxylamine hydrochloride; potassium carbonate; In ethanol; at 20 ℃;

Reference yield:

3-(chloromethyl)-2-(4-chlorophenyl)imidazo[1,2-a]pyridine hydrochloride → 2-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)-N'-hydroxyacetimidamide (1197849-54-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium iodide / tetra-n-butylammonium cyanide / acetonitrile / 20 °C

2: hydroxylamine hydrochloride; potassium carbonate / ethanol / 20 °C

With hydroxylamine hydrochloride; potassium carbonate; sodium iodide; tetra-n-butylammonium cyanide; In ethanol; acetonitrile;

Reference yield: 58.0%

2-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)-N'-hydroxyacetimidamide (1197849-54-9) + Ethyl oxalyl chloride (4755-77-5) → ethyl 3-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-1,2,4-oxadiazole-5-carboxylate (1197849-04-9)

Guidance literature:

With pyridine; In chloroform; at -40 - 80 ℃; Inert atmosphere; Cooling with ethanol-dry ice;

upstream raw materials:

2-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)acetonitrile

Downstream raw materials:

ethyl 3-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-1,2,4-oxadiazole-5-carboxylate

3-((6-fluoro-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-1,2,4-oxadiazol-5(4H)-one

3-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-1,2,4-oxadiazole-5-carbohydrazide

3-((2-(4-chlorophenyl)-6-fluoroimidazo[1,2-a]pyridin-3-yl)methyl)-N-hydroxy-1,2,4-oxadiazole-5-carboxamide

Refernces