ethyl 3-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-1,2,4-oxadiazole-5-carboxylate

Base Information

Chemical Name:ethyl 3-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-1,2,4-oxadiazole-5-carboxylate
CAS No.:1197849-04-9
Molecular Formula:C₁₉H₁₅ClN₄O₃
Molecular Weight:382.806
Hs Code.:

Synonyms:ethyl 3-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-1,2,4-oxadiazole-5-carboxylate

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Chemical Property of ethyl 3-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-1,2,4-oxadiazole-5-carboxylate

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Technology Process of ethyl 3-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-1,2,4-oxadiazole-5-carboxylate

There total 3 articles about ethyl 3-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-1,2,4-oxadiazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1197849-54-9
2-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)-N'-hydroxyacetimidamide

: 4755-77-5
Ethyl oxalyl chloride

: 1197849-04-9
ethyl 3-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-1,2,4-oxadiazole-5-carboxylate

Guidance literature:: With pyridine; In chloroform; at -40 - 80 ℃; Inert atmosphere; Cooling with ethanol-dry ice;

Reference yield:

: 3-(chloromethyl)-2-(4-chlorophenyl)imidazo[1,2-a]pyridine hydrochloride

: 1197849-04-9
ethyl 3-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-1,2,4-oxadiazole-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium iodide / tetra-n-butylammonium cyanide / acetonitrile / 20 °C

2: hydroxylamine hydrochloride; potassium carbonate / ethanol / 20 °C

3: pyridine / chloroform / -40 - 80 °C / Inert atmosphere; Cooling with ethanol-dry ice

With pyridine; hydroxylamine hydrochloride; potassium carbonate; sodium iodide; tetra-n-butylammonium cyanide; In ethanol; chloroform; acetonitrile;

Reference yield:

: 17744-99-9
2-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)acetonitrile

: 1197849-04-9
ethyl 3-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-1,2,4-oxadiazole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; potassium carbonate / ethanol / 20 °C

2: pyridine / chloroform / -40 - 80 °C / Inert atmosphere; Cooling with ethanol-dry ice

With pyridine; hydroxylamine hydrochloride; potassium carbonate; In ethanol; chloroform;