3-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}-5-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-1-yl]-2-thiophenecarboxamide

Base Information

Chemical Name:3-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}-5-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-1-yl]-2-thiophenecarboxamide
CAS No.:929278-56-8
Molecular Formula:C₂₆H₂₇BClN₃O₄S
Molecular Weight:523.848
Hs Code.:

Synonyms:3-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}-5-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-1-yl]-2-thiophenecarboxamide

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Chemical Property of 3-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}-5-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-1-yl]-2-thiophenecarboxamide

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Technology Process of 3-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}-5-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-1-yl]-2-thiophenecarboxamide

There total 1 articles about 3-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}-5-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-1-yl]-2-thiophenecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 929040-33-5
5-(5-bromo-1H-benzimidazol-1-yl)-3-({(1R)-1-[2-chlorophenyl]ethyl}oxy)thiophene-2-carboxamide

: 73183-34-3
bis(pinacol)diborane

: 929278-56-8
3-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}-5-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-1-yl]-2-thiophenecarboxamide

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; potassium acetate; In N,N-dimethyl-formamide; at 150 ℃; for 0.333333h; Microwave irradiation;
DOI:10.1016/j.tetlet.2009.01.087

Reference yield: 79.0%

: 3934-20-1
2,6-Dichloropyrimidine

: 929278-56-8
3-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}-5-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-1-yl]-2-thiophenecarboxamide

: 5-[5-(2-chloropyrimidin-4-yl)-1H-benzimidazol-1-yl]-3-({(1R)-1-[2-chlorophenyl]ethyl}oxy)thiophene-2-carboxamide

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In N,N-dimethyl acetamide; water; at 80 ℃; for 10h; Inert atmosphere;
DOI:10.1016/j.tetlet.2009.01.087

Reference yield: 64.0%

: 38373-44-3
5-chloro-2-methoxypyrimidine

: 929278-56-8
3-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}-5-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-1-yl]-2-thiophenecarboxamide

: 1140502-20-0
5-[5-(2-methoxypyrimidin-5-yl)-1H-benzimidazol-1-yl]-3-({(1R)-1-[2-chlorophenyl]ethyl}oxy)thiophene-2-carboxamide

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In N,N-dimethyl acetamide; water; at 80 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.tetlet.2009.01.087