4-N-[6-ethylthieno[2,3-d]pyrimidin-4-yl]-1-N,1-N-dimethylcyclohexane-1,4-diamine

Base Information

• Chemical Name: 4-N-[6-ethylthieno[2,3-d]pyrimidin-4-yl]-1-N,1-N-dimethylcyclohexane-1,4-diamine
• CAS No.: 1388891-99-3
• Molecular Formula: C₁₆H₂₄N₄S
• Molecular Weight: 304.459
• Mol file: 1388891-99-3.mol

Synonyms:4-N-[6-ethylthieno[2,3-d]pyrimidin-4-yl]-1-N,1-N-dimethylcyclohexane-1,4-diamine

Chemical Property of 4-N-[6-ethylthieno[2,3-d]pyrimidin-4-yl]-1-N,1-N-dimethylcyclohexane-1,4-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-N-[6-ethylthieno[2,3-d]pyrimidin-4-yl]-1-N,1-N-dimethylcyclohexane-1,4-diamine

There total 1 articles about 4-N-[6-ethylthieno[2,3-d]pyrimidin-4-yl]-1-N,1-N-dimethylcyclohexane-1,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + C14H20N4S (1388891-97-1) → 4-N-[6-ethylthieno[2,3-d]pyrimidin-4-yl]-1-N,1-N-dimethylcyclohexane-1,4-diamine (1388891-99-3)

Guidance literature:

formaldehyd; C₁₄H₂₀N₄S; With formic acid; Reflux;

With sodium carbonate; at 20 ℃; pH=9; Product distribution / selectivity;

Reference yield: 60.0%

4-N-[6-ethylthieno[2,3-d]pyrimidin-4-yl]-1-N,1-N-dimethylcyclohexane-1,4-diamine (1388891-99-3) → 4-N-(5-bromo-6-ethylthieno[2,3-d]pyrimidin-4-yl)-1-N,1-N-dimethylcyclohexane-1,4-diamine (1388892-70-3)

Guidance literature:

With bromine; In acetic acid; at 70 ℃;

Reference yield: 37.0%

4-N-[6-ethylthieno[2,3-d]pyrimidin-4-yl]-1-N,1-N-dimethylcyclohexane-1,4-diamine (1388891-99-3) + ethyl iodide (75-03-6) → 1-N-ethyl-1-N-[6-ethylthieno[2,3-d]pyrimidin-4-yl]-4-N,4-N-dimethylcyclohexane-1,4-diamine (1388892-01-0)

Guidance literature:

4-N-[6-ethylthieno[2,3-d]pyrimidin-4-yl]-1-N,1-N-dimethylcyclohexane-1,4-diamine; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 10 ℃; Inert atmosphere;

ethyl iodide; In N,N-dimethyl-formamide; at 10 ℃;

upstream raw materials:

formaldehyd

C₁₄H₂₀N₄S

Downstream raw materials:

1-N-ethyl-1-N-[6-ethylthieno[2,3-d]pyrimidin-4-yl]-4-N,4-N-dimethylcyclohexane-1,4-diamine

4-N-(5-bromo-6-ethylthieno[2,3-d]pyrimidin-4-yl)-1-N,1-N-dimethylcyclohexane-1,4-diamine

4-N-[6-ethyl-5-(pyridin-2-yl)thieno[2,3-d]pyrimidin-4-yl]-1-N,1-N-dimethylcyclohexane-1,4-diamine

4-N-[5-(1-benzofuran-2-yl)-6-ethylthieno[2,3-d]pyrimidin-4-yl]-1-N,1-N-dimethylcyclohexane-1,4-diamine