diethyl 2-acetylamino-2-(2-(4-(3-ethoxycarbonylpropyl)phenyl)ethyl)propane-1,3-dioate

Base Information

Chemical Name:diethyl 2-acetylamino-2-(2-(4-(3-ethoxycarbonylpropyl)phenyl)ethyl)propane-1,3-dioate
CAS No.:896472-82-5
Molecular Formula:C₂₃H₃₃NO₇
Molecular Weight:435.518
Hs Code.:

Synonyms:diethyl 2-acetylamino-2-(2-(4-(3-ethoxycarbonylpropyl)phenyl)ethyl)propane-1,3-dioate

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Chemical Property of diethyl 2-acetylamino-2-(2-(4-(3-ethoxycarbonylpropyl)phenyl)ethyl)propane-1,3-dioate

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Technology Process of diethyl 2-acetylamino-2-(2-(4-(3-ethoxycarbonylpropyl)phenyl)ethyl)propane-1,3-dioate

There total 5 articles about diethyl 2-acetylamino-2-(2-(4-(3-ethoxycarbonylpropyl)phenyl)ethyl)propane-1,3-dioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 4-[4-(2-iodo-ethyl)-phenyl]-butyric acid ethyl ester

: 896472-82-5
diethyl 2-acetylamino-2-(2-(4-(3-ethoxycarbonylpropyl)phenyl)ethyl)propane-1,3-dioate

Guidance literature:: With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(99)00695-2

Reference yield: 81.0%

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 167264-38-2
ethyl 4-(4-(2-bromoethyl)phenyl)butyrate

: 896472-82-5
diethyl 2-acetylamino-2-(2-(4-(3-ethoxycarbonylpropyl)phenyl)ethyl)propane-1,3-dioate

Guidance literature:: 2-acetylaminomalonic acid diethyl ester; With sodium hydride; In N,N-dimethyl-formamide; at 90 ℃;

ethyl 4-(4-(2-bromoethyl)phenyl)butyrate; In tetrahydrofuran; N,N-dimethyl-formamide; for 2h; Heating;
DOI:10.1016/j.bmc.2006.01.071

Reference yield:

: 10031-93-3
ethyl 4-phenylbutyrate

: 896472-82-5
diethyl 2-acetylamino-2-(2-(4-(3-ethoxycarbonylpropyl)phenyl)ethyl)propane-1,3-dioate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 88 percent / AlCl₃ / CHCl₃ / 2.25 h / -10 - 20 °C

2.1: 68 percent / triethylsilane; trifluoroacetic acid / 4 h / 20 °C

3.1: sodium hydride / dimethylformamide / 90 °C

3.2: 81 percent / dimethylformamide; tetrahydrofuran / 2 h / Heating

With triethylsilane; aluminium trichloride; sodium hydride; trifluoroacetic acid; In chloroform; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.01.071