ethyl 4-(4-(2-(5-acetylamino-2,2-dimethyl-1,3-dioxan-5-yl)ethyl)phenyl)butanoate

Base Information

Chemical Name:ethyl 4-(4-(2-(5-acetylamino-2,2-dimethyl-1,3-dioxan-5-yl)ethyl)phenyl)butanoate
CAS No.:896472-83-6
Molecular Formula:C₂₂H₃₃NO₅
Molecular Weight:391.508
Hs Code.:

Synonyms:ethyl 4-(4-(2-(5-acetylamino-2,2-dimethyl-1,3-dioxan-5-yl)ethyl)phenyl)butanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 4-(4-(2-(5-acetylamino-2,2-dimethyl-1,3-dioxan-5-yl)ethyl)phenyl)butanoate

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Technology Process of ethyl 4-(4-(2-(5-acetylamino-2,2-dimethyl-1,3-dioxan-5-yl)ethyl)phenyl)butanoate

There total 1 articles about ethyl 4-(4-(2-(5-acetylamino-2,2-dimethyl-1,3-dioxan-5-yl)ethyl)phenyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 77-76-9
2,2-dimethoxy-propane

: 896472-82-5
diethyl 2-acetylamino-2-(2-(4-(3-ethoxycarbonylpropyl)phenyl)ethyl)propane-1,3-dioate

: 896472-84-7
N-(5-(2-(4-(4-hydroxybutyl)phenyl)ethyl)-2,2-dimethyl-1,3-dioxan-5-yl)ethanamide

: 896472-83-6
ethyl 4-(4-(2-(5-acetylamino-2,2-dimethyl-1,3-dioxan-5-yl)ethyl)phenyl)butanoate

Guidance literature:: diethyl 2-acetylamino-2-(2-(4-(3-ethoxycarbonylpropyl)phenyl)ethyl)propane-1,3-dioate; With sodium tetrahydroborate; In methanol;

2,2-dimethoxy-propane; With toluene-4-sulfonic acid;
DOI:10.1016/S0960-894X(99)00695-2

Reference yield: 67.0%

: 896472-83-6
ethyl 4-(4-(2-(5-acetylamino-2,2-dimethyl-1,3-dioxan-5-yl)ethyl)phenyl)butanoate

: 896472-84-7
N-(5-(2-(4-(4-hydroxybutyl)phenyl)ethyl)-2,2-dimethyl-1,3-dioxan-5-yl)ethanamide

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether;
DOI:10.1016/S0960-894X(99)00695-2

Reference yield:

: 896472-83-6
ethyl 4-(4-(2-(5-acetylamino-2,2-dimethyl-1,3-dioxan-5-yl)ethyl)phenyl)butanoate

: 896472-87-0
N-(5-(2-(4-(8-hydroxyoctyl)phenyl)ethyl)-2,2-dimethyl-1,3-dioxan-5-yl)ethanamide

Guidance literature:: Multi-step reaction with 5 steps

1: 67 percent / lithium aluminum hydride / diethyl ether / 2 h / 20 °C

2: 93 percent / oxalyl chloride / CH₂Cl₂; dimethylsulfoxide / 0.17 h / -70 °C

3: 52 percent / sodium hydride / dimethylformamide / 0.5 h / -25 °C

4: 99 percent / hydrogen / Pd/C / ethyl acetate / 2 h

5: 72 percent / lithium aluminum hydride / diethyl ether / 2 h / 20 °C

With lithium aluminium tetrahydride; oxalyl dichloride; hydrogen; sodium hydride; palladium on activated charcoal; In diethyl ether; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; 3: Wittig condensation;
DOI:10.1016/j.bmc.2006.01.071