(2S,4R)-2-trifluoromethyl-4-phenyl-3-propenoyloxazolidine

Base Information

• Chemical Name: (2S,4R)-2-trifluoromethyl-4-phenyl-3-propenoyloxazolidine
• CAS No.: 1026021-02-2
• Molecular Formula: C₁₃H₁₂F₃NO₂
• Molecular Weight: 271.239
• Mol file: 1026021-02-2.mol

Synonyms:(2S,4R)-2-trifluoromethyl-4-phenyl-3-propenoyloxazolidine

Chemical Property of (2S,4R)-2-trifluoromethyl-4-phenyl-3-propenoyloxazolidine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (2S,4R)-2-trifluoromethyl-4-phenyl-3-propenoyloxazolidine

There total 1 articles about (2S,4R)-2-trifluoromethyl-4-phenyl-3-propenoyloxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

2-chloropropionyl chloride (625-36-5) + (4R)-2-trifluoromethyl-4-phenyl-1,3-oxazolidine (1044222-31-2) → (2R,4R)-2-trifluoromethyl-4-phenyl-3-propenoyloxazolidine (1026021-03-3) + (2S,4R)-2-trifluoromethyl-4-phenyl-3-propenoyloxazolidine (1026021-02-2)

Guidance literature:

With triethylamine; at -10 - 20 ℃;

DOI:10.1021/jo800562x

Reference yield: 87.0%

(2S,4R)-2-trifluoromethyl-4-phenyl-3-propenoyloxazolidine (1026021-02-2) + dibenzylamine (103-49-1) → (2S,4R)-2-trifluoromethyl-4-phenyl-3-(3-(N,N-dibenzylamino)propanoyl)oxazolidine (1026021-04-4)

Guidance literature:

With triethylamine; at 50 ℃; for 30h;

DOI:10.1021/jo800562x

upstream raw materials:

2-chloropropionyl chloride

(4R)-2-trifluoromethyl-4-phenyl-1,3-oxazolidine

Downstream raw materials:

(2S,4R)-2-trifluoromethyl-4-phenyl-3-(3-(N,N-dibenzylamino)propanoyl)oxazolidine