5-chlorothiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]-3-(4-methylpiperazin-1-yl)-3-oxopropyl]amide hydrochloride

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Chemical Name:5-chlorothiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]-3-(4-methylpiperazin-1-yl)-3-oxopropyl]amide hydrochloride
CAS No.:1184298-38-1
Molecular Formula:C₂₄H₃₀ClN₅O₅S₂*ClH
Molecular Weight:604.579
Hs Code.:

5-chlorothiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]-3-(4-methylpiperazin-1-yl)-3-oxopropyl]amide hydrochloride

Synonyms:5-chlorothiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]-3-(4-methylpiperazin-1-yl)-3-oxopropyl]amide hydrochloride

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Chemical Property of 5-chlorothiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]-3-(4-methylpiperazin-1-yl)-3-oxopropyl]amide hydrochloride

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Technology Process of 5-chlorothiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]-3-(4-methylpiperazin-1-yl)-3-oxopropyl]amide hydrochloride

There total 11 articles about 5-chlorothiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]-3-(4-methylpiperazin-1-yl)-3-oxopropyl]amide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 109-01-3
1-methyl-piperazine

: 1184298-40-5
(S)-3-[(5-chlorothiophene-2-carbonyl)amino]-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]propionic acid

: 1184298-38-1
5-chlorothiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]-3-(4-methylpiperazin-1-yl)-3-oxopropyl]amide hydrochloride

Guidance literature:: 1-methyl-piperazine; (S)-3-[(5-chlorothiophene-2-carbonyl)amino]-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]propionic acid; With 2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethylisouronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h;

With hydrogenchloride; In diethyl ether; dichloromethane;
DOI:10.1021/jm4005835

Reference yield:

: 69321-60-4
2,6-dibromotoluene

: 1184298-38-1
5-chlorothiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]-3-(4-methylpiperazin-1-yl)-3-oxopropyl]amide hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium; sulfur / tetrahydrofuran; n-heptane / 0.75 h / -78 °C / Inert atmosphere

1.2: 1.5 h / -78 °C / Inert atmosphere

2.1: potassium carbonate; copper(l) iodide; N,N,N,N,-tetramethylethylenediamine / toluene / 20 h / 110 °C / Inert atmosphere

3.1: acetic acid; sulfuryl dichloride / water; dichloromethane / 1.58 h / 0 - 20 °C

4.1: triethylamine / dichloromethane / 16 h / 0 - 20 °C

5.1: water; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; 2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethylisouronium hexafluorophosphate / dichloromethane / 1 h / 20 °C

With copper(l) iodide; n-butyllithium; sulfuryl dichloride; 2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethylisouronium hexafluorophosphate; N,N,N,N,-tetramethylethylenediamine; water; potassium carbonate; sulfur; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; n-heptane; dichloromethane; water; toluene;
DOI:10.1021/jm4005835

Reference yield:

: 1182728-66-0
1-benzylsulfanyl-3-bromo-2-methyl-benzene

: 1184298-38-1
5-chlorothiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]-3-(4-methylpiperazin-1-yl)-3-oxopropyl]amide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate; copper(l) iodide; N,N,N,N,-tetramethylethylenediamine / toluene / 20 h / 110 °C / Inert atmosphere

2: acetic acid; sulfuryl dichloride / water; dichloromethane / 1.58 h / 0 - 20 °C

3: triethylamine / dichloromethane / 16 h / 0 - 20 °C

4: water; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; 2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethylisouronium hexafluorophosphate / dichloromethane / 1 h / 20 °C

With copper(l) iodide; sulfuryl dichloride; 2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethylisouronium hexafluorophosphate; N,N,N,N,-tetramethylethylenediamine; water; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; toluene;
DOI:10.1021/jm4005835