5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxo-pyrrolidin-1-yl)-benzenesulfonylamino]-3-(4-methyl-4-oxy-piperazin-1-yl)-3-oxo-propyl]-amide hydrochloride

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Chemical Name:5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxo-pyrrolidin-1-yl)-benzenesulfonylamino]-3-(4-methyl-4-oxy-piperazin-1-yl)-3-oxo-propyl]-amide hydrochloride
CAS No.:1306744-59-1
Molecular Formula:C₂₄H₃₀ClN₅O₆S₂*ClH
Molecular Weight:620.578
Hs Code.:

5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxo-pyrrolidin-1-yl)-benzenesulfonylamino]-3-(4-methyl-4-oxy-piperazin-1-yl)-3-oxo-propyl]-amide hydrochloride

Synonyms:5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxo-pyrrolidin-1-yl)-benzenesulfonylamino]-3-(4-methyl-4-oxy-piperazin-1-yl)-3-oxo-propyl]-amide hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxo-pyrrolidin-1-yl)-benzenesulfonylamino]-3-(4-methyl-4-oxy-piperazin-1-yl)-3-oxo-propyl]-amide hydrochloride

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxo-pyrrolidin-1-yl)-benzenesulfonylamino]-3-(4-methyl-4-oxy-piperazin-1-yl)-3-oxo-propyl]-amide hydrochloride

There total 10 articles about 5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxo-pyrrolidin-1-yl)-benzenesulfonylamino]-3-(4-methyl-4-oxy-piperazin-1-yl)-3-oxo-propyl]-amide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1184298-38-1
5-chlorothiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]-3-(4-methylpiperazin-1-yl)-3-oxopropyl]amide hydrochloride

: 1306744-59-1
5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxo-pyrrolidin-1-yl)-benzenesulfonylamino]-3-(4-methyl-4-oxy-piperazin-1-yl)-3-oxo-propyl]-amide hydrochloride

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

: 1182728-66-0
1-benzylsulfanyl-3-bromo-2-methyl-benzene

: 1306744-59-1
5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxo-pyrrolidin-1-yl)-benzenesulfonylamino]-3-(4-methyl-4-oxy-piperazin-1-yl)-3-oxo-propyl]-amide hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / copper(l) iodide; N,N`-dimethylethylenediamine / toluene / 16 h / 110 °C / Inert atmosphere

2: sulfuryl dichloride; water; acetic acid / dichloromethane / 0.42 h / 0 - 20 °C

3: triethylamine / dichloromethane / 0 °C

4: water; sodium hydroxide / tetrahydrofuran / 2 h / 20 °C

5: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

6: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / 20 °C

With sulfuryl dichloride; water; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; copper(l) iodide; N,N`-dimethylethylenediamine; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 69321-60-4
2,6-dibromotoluene

: 1306744-59-1
5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxo-pyrrolidin-1-yl)-benzenesulfonylamino]-3-(4-methyl-4-oxy-piperazin-1-yl)-3-oxo-propyl]-amide hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: N-ethyl-N,N-diisopropylamine / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 100 °C / Inert atmosphere

2: potassium carbonate / copper(l) iodide; N,N`-dimethylethylenediamine / toluene / 16 h / 110 °C / Inert atmosphere

3: sulfuryl dichloride; water; acetic acid / dichloromethane / 0.42 h / 0 - 20 °C

4: triethylamine / dichloromethane / 0 °C

5: water; sodium hydroxide / tetrahydrofuran / 2 h / 20 °C

6: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

7: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / 20 °C

With sulfuryl dichloride; water; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; N,N`-dimethylethylenediamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene;