(S)-3-[(5-chlorothiophene-2-carbonyl)amino]-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]propionic acid

Base Information

Chemical Name:(S)-3-[(5-chlorothiophene-2-carbonyl)amino]-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]propionic acid
CAS No.:1184298-40-5
Molecular Formula:C₁₉H₂₀ClN₃O₆S₂
Molecular Weight:485.969
Hs Code.:

Synonyms:(S)-3-[(5-chlorothiophene-2-carbonyl)amino]-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]propionic acid

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Chemical Property of (S)-3-[(5-chlorothiophene-2-carbonyl)amino]-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]propionic acid

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Technology Process of (S)-3-[(5-chlorothiophene-2-carbonyl)amino]-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]propionic acid

There total 10 articles about (S)-3-[(5-chlorothiophene-2-carbonyl)amino]-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1184298-39-2
(S)-3-[(5-chlorothiophene-2-carbonyl)amino]-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]propionic acid methyl ester

: 1184298-40-5
(S)-3-[(5-chlorothiophene-2-carbonyl)amino]-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]propionic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/jm4005835

Reference yield:

: 1182728-66-0
1-benzylsulfanyl-3-bromo-2-methyl-benzene

: 1184298-40-5
(S)-3-[(5-chlorothiophene-2-carbonyl)amino]-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; copper(l) iodide; N,N,N,N,-tetramethylethylenediamine / toluene / 20 h / 110 °C / Inert atmosphere

2: acetic acid; sulfuryl dichloride / water; dichloromethane / 1.58 h / 0 - 20 °C

3: triethylamine / dichloromethane / 16 h / 0 - 20 °C

4: water; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C

With copper(l) iodide; sulfuryl dichloride; N,N,N,N,-tetramethylethylenediamine; water; potassium carbonate; acetic acid; triethylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; toluene;
DOI:10.1021/jm4005835

Reference yield:

: 69321-60-4
2,6-dibromotoluene

: 1184298-40-5
(S)-3-[(5-chlorothiophene-2-carbonyl)amino]-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium; sulfur / tetrahydrofuran; n-heptane / 0.75 h / -78 °C / Inert atmosphere

1.2: 1.5 h / -78 °C / Inert atmosphere

2.1: potassium carbonate; copper(l) iodide; N,N,N,N,-tetramethylethylenediamine / toluene / 20 h / 110 °C / Inert atmosphere

3.1: acetic acid; sulfuryl dichloride / water; dichloromethane / 1.58 h / 0 - 20 °C

4.1: triethylamine / dichloromethane / 16 h / 0 - 20 °C

5.1: water; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C

With copper(l) iodide; n-butyllithium; sulfuryl dichloride; N,N,N,N,-tetramethylethylenediamine; water; potassium carbonate; sulfur; acetic acid; triethylamine; lithium hydroxide; In tetrahydrofuran; n-heptane; dichloromethane; water; toluene;
DOI:10.1021/jm4005835