2-benzyl-1-(2H)-isoquinoline ketone

Base Information

• Chemical Name: 2-benzyl-1-(2H)-isoquinoline ketone
• CAS No.: 59168-21-7
• Molecular Formula: C₁₆H₁₃NO
• Molecular Weight: 235.285
• Mol file: 59168-21-7.mol

Synonyms:2-benzyl-1-(2H)-isoquinoline ketone

Chemical Property of 2-benzyl-1-(2H)-isoquinoline ketone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-benzyl-1-(2H)-isoquinoline ketone

There total 64 articles about 2-benzyl-1-(2H)-isoquinoline ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

benzyl chloride (100-44-7) + 1-isoquinolone (491-30-5) → 2-benzyl-1-(2H)-isoquinoline ketone (59168-21-7)

Guidance literature:

With potassium hydroxide; In ethanol; at 100 ℃; for 10h;

DOI:10.1248/cpb.50.225

Reference yield: 95.0%

2-benzylisoquinolin-2-ium bromide (23277-04-5) → 2-benzyl-1-(2H)-isoquinoline ketone (59168-21-7)

Guidance literature:

With potassium tert-butylate; In dimethyl sulfoxide; at 20 ℃; for 24h; Reagent/catalyst; Solvent; Time; Green chemistry;

DOI:10.1039/c9gc03629f

Reference yield: 94.0%

1-hydroxyisoquinoline (491-30-5,87602-67-3) → 2-benzyl-1-(2H)-isoquinoline ketone (59168-21-7)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 3h;

DOI:10.1002/ejoc.202001371

upstream raw materials:

1,2,3,4-tetrahydroisoquinoline

benzaldehyde

2-benzylisoquinolin-2-ium bromide

2-benzylisoquinolinium

Downstream raw materials:

2-benzyl-1,2-dihydro-1-[bis(cyano)methylene]isoquinoline

2-benzyl-1,2-dihydro-1-[cyano(methoxycarbonyl)methylene]isoquinoline

2-benzyl-1,2-dihydro-1-[bis(methoxycarbonyl)methylene]isoquinoline

N-benzylisoquinoline-1,3,4(2H)-trione

Refernces

• 1、 Zhou, Meimei,Yu, Keyang,Liu, Jianxin,Shi, Weimei,Pan, Yingming,Tang, Haitao,Peng, Xiangjun,Liu, Qian,Wang, Hengshan. "Light-driven selective aerobic oxidation of (iso)quinoliniums and related heterocycles". . p. 16246 - 16251. Retrieved 2021/05/19.
• 2、 Chandra, Devesh,Gupta, Puneet,Kumar, Nikunj,Parmar, Diksha,Sharma, Upendra,Sumit. "Co(iii)-catalysed regioselective linear C(8)-H olefination of isoquinolone with terminal aromatic and aliphatic alkynes". supporting information. p. 11613 - 11616. Retrieved 2021/11/12.