Benzenesulfonyl-5-(5-bromo-2-methyl-2H-pyrazol-3-yl)-2-(2,6-difluoro-phenyl)-1H-indole

Base Information

Chemical Name:Benzenesulfonyl-5-(5-bromo-2-methyl-2H-pyrazol-3-yl)-2-(2,6-difluoro-phenyl)-1H-indole
CAS No.:1279106-87-4
Molecular Formula:C₂₄H₁₆BrF₂N₃O₂S
Molecular Weight:528.377
Hs Code.:

Synonyms:Benzenesulfonyl-5-(5-bromo-2-methyl-2H-pyrazol-3-yl)-2-(2,6-difluoro-phenyl)-1H-indole

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Chemical Property of Benzenesulfonyl-5-(5-bromo-2-methyl-2H-pyrazol-3-yl)-2-(2,6-difluoro-phenyl)-1H-indole

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Technology Process of Benzenesulfonyl-5-(5-bromo-2-methyl-2H-pyrazol-3-yl)-2-(2,6-difluoro-phenyl)-1H-indole

There total 6 articles about Benzenesulfonyl-5-(5-bromo-2-methyl-2H-pyrazol-3-yl)-2-(2,6-difluoro-phenyl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1279106-86-3
5-[1 Benzenesulfonyl-2-(2,6-difluoro-phenyl)-1H-indol-5-yl]-1-methyl-1H-pyrazol-3-ylamine

: 1279106-87-4
Benzenesulfonyl-5-(5-bromo-2-methyl-2H-pyrazol-3-yl)-2-(2,6-difluoro-phenyl)-1H-indole

Guidance literature:: 5-[1 Benzenesulfonyl-2-(2,6-difluoro-phenyl)-1H-indol-5-yl]-1-methyl-1H-pyrazol-3-ylamine; With sodium nitrite; sulfuric acid; In water; acetonitrile; for 0.5h; Cooling with ice;

With hydrogen bromide; copper(I) bromide; In water; acetonitrile; at 0 ℃; for 0.5h;

Reference yield:

: 13670-99-0
2,6-difluoroacetophenone

: 1279106-87-4
Benzenesulfonyl-5-(5-bromo-2-methyl-2H-pyrazol-3-yl)-2-(2,6-difluoro-phenyl)-1H-indole

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium acetate / ethanol / 16 h / 25 °C

2.1: polyphosphoric acid / 2 h / 130 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

3.2: 0 - 25 °C

4.1: potassium carbonate / 1,4-dioxane / 25 - 110 °C

5.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

6.1: sodium nitrite / sulfuric acid / water; acetonitrile / 0.5 h / Cooling with ice

6.2: 0.5 h / 0 °C

With potassium acetate; sodium hydride; potassium carbonate; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sulfuric acid; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1188072-92-5
5-bromo-2-(2,6-difluoro-phenyl)-1H-indole

: 1279106-87-4
Benzenesulfonyl-5-(5-bromo-2-methyl-2H-pyrazol-3-yl)-2-(2,6-difluoro-phenyl)-1H-indole

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 0 - 25 °C

2.1: potassium carbonate / 1,4-dioxane / 25 - 110 °C

3.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

4.1: sodium nitrite / sulfuric acid / water; acetonitrile / 0.5 h / Cooling with ice

4.2: 0.5 h / 0 °C

With sodium hydride; potassium carbonate; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sulfuric acid; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;