5-[1 Benzenesulfonyl-2-(2,6-difluoro-phenyl)-1H-indol-5-yl]-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester

Base Information

Chemical Name:5-[1 Benzenesulfonyl-2-(2,6-difluoro-phenyl)-1H-indol-5-yl]-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester
CAS No.:1279106-89-6
Molecular Formula:C₂₆H₁₉F₂N₃O₄S
Molecular Weight:507.517
Hs Code.:

Synonyms:5-[1 Benzenesulfonyl-2-(2,6-difluoro-phenyl)-1H-indol-5-yl]-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester

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Chemical Property of 5-[1 Benzenesulfonyl-2-(2,6-difluoro-phenyl)-1H-indol-5-yl]-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester

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Technology Process of 5-[1 Benzenesulfonyl-2-(2,6-difluoro-phenyl)-1H-indol-5-yl]-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester

There total 7 articles about 5-[1 Benzenesulfonyl-2-(2,6-difluoro-phenyl)-1H-indol-5-yl]-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 201230-82-2
carbon monoxide

: 1279106-87-4
Benzenesulfonyl-5-(5-bromo-2-methyl-2H-pyrazol-3-yl)-2-(2,6-difluoro-phenyl)-1H-indole

: 1279106-89-6
5-[1 Benzenesulfonyl-2-(2,6-difluoro-phenyl)-1H-indol-5-yl]-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester

Guidance literature:: With 1,3-bis-(diphenylphosphino)propane; triethylamine; palladium diacetate; In methanol; at 80 ℃; for 18h; under 11377.6 Torr; Inert atmosphere; Autoclave;

Reference yield:

: 13670-99-0
2,6-difluoroacetophenone

: 1279106-89-6
5-[1 Benzenesulfonyl-2-(2,6-difluoro-phenyl)-1H-indol-5-yl]-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium acetate / ethanol / 16 h / 25 °C

2.1: polyphosphoric acid / 2 h / 130 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

3.2: 0 - 25 °C

4.1: potassium carbonate / 1,4-dioxane / 25 - 110 °C

5.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

6.1: sodium nitrite / sulfuric acid / water; acetonitrile / 0.5 h / Cooling with ice

6.2: 0.5 h / 0 °C

7.1: 1,3-bis-(diphenylphosphino)propane; triethylamine / palladium diacetate / methanol / 18 h / 80 °C / 11377.6 Torr / Inert atmosphere; Autoclave

With 1,3-bis-(diphenylphosphino)propane; potassium acetate; sodium hydride; potassium carbonate; triethylamine; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sulfuric acid; palladium diacetate; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1188072-92-5
5-bromo-2-(2,6-difluoro-phenyl)-1H-indole

: 1279106-89-6
5-[1 Benzenesulfonyl-2-(2,6-difluoro-phenyl)-1H-indol-5-yl]-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 0 - 25 °C

2.1: potassium carbonate / 1,4-dioxane / 25 - 110 °C

3.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

4.1: sodium nitrite / sulfuric acid / water; acetonitrile / 0.5 h / Cooling with ice

4.2: 0.5 h / 0 °C

5.1: 1,3-bis-(diphenylphosphino)propane; triethylamine / palladium diacetate / methanol / 18 h / 80 °C / 11377.6 Torr / Inert atmosphere; Autoclave

With 1,3-bis-(diphenylphosphino)propane; sodium hydride; potassium carbonate; triethylamine; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sulfuric acid; palladium diacetate; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; acetonitrile;