(2R,3R)-3-(3-hydroxyphenyl)-2-methylpentanoic acid chloride

Base Information

Chemical Name:(2R,3R)-3-(3-hydroxyphenyl)-2-methylpentanoic acid chloride
CAS No.:1384457-50-4
Molecular Formula:C₁₂H₁₅ClO₂
Molecular Weight:226.703
Hs Code.:

Synonyms:(2R,3R)-3-(3-hydroxyphenyl)-2-methylpentanoic acid chloride

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Chemical Property of (2R,3R)-3-(3-hydroxyphenyl)-2-methylpentanoic acid chloride

Chemical Property:

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Technology Process of (2R,3R)-3-(3-hydroxyphenyl)-2-methylpentanoic acid chloride

There total 7 articles about (2R,3R)-3-(3-hydroxyphenyl)-2-methylpentanoic acid chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1384457-52-6
(1R,2R)-3-(3-hydroxyphenyl)-2-methyl-pentanoic acid

: 1384457-50-4
(2R,3R)-3-(3-hydroxyphenyl)-2-methylpentanoic acid chloride

Guidance literature:: With thionyl chloride; N,N-dimethyl-formamide; In toluene; at 88 ℃; for 3.5h; Inert atmosphere;

Reference yield:

: 208836-69-5
3-(3'-benzyloxyphenyl)-(E)-propenoic acid ethyl ester

: 1384457-50-4
(2R,3R)-3-(3-hydroxyphenyl)-2-methylpentanoic acid chloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: diisobutylaluminium hydride / toluene / -10 - 0 °C / Inert atmosphere

1.2: 5 °C

2.1: carbon tetrabromide / 10.33 h / 62 °C / Inert atmosphere

3.1: triethylamine; lithium hexamethyldisilazane / toluene / 2.5 h / -65 °C / Inert atmosphere

3.2: 0.17 h / 20 - 30 °C

3.3: pH 1 - 2 / Cooling with ice

4.1: ethanol / 20 - 40 °C / Resolution of racemate; Reflux

5.1: hydrogenchloride / water; tert-butyl methyl ether / 0.25 h / 20 °C

6.1: hydrogen / 5%-palladium/activated carbon / methanol / 15 h / 20 °C

7.1: thionyl chloride / N,N-dimethyl-formamide / toluene / 3.5 h / 88 °C / Inert atmosphere

With hydrogenchloride; thionyl chloride; hydrogen; diisobutylaluminium hydride; triethylamine; lithium hexamethyldisilazane; carbon tetrabromide; 5%-palladium/activated carbon; N,N-dimethyl-formamide; In methanol; ethanol; tert-butyl methyl ether; water; toluene;

Reference yield:

: (2RS,3RS)-3-(3-benzyloxyphenyl)-2-methylpent-4-enoic acid

: 1384457-50-4
(2R,3R)-3-(3-hydroxyphenyl)-2-methylpentanoic acid chloride

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 20 - 40 °C / Resolution of racemate; Reflux

2: hydrogenchloride / water; tert-butyl methyl ether / 0.25 h / 20 °C

3: hydrogen / 5%-palladium/activated carbon / methanol / 15 h / 20 °C

4: thionyl chloride / N,N-dimethyl-formamide / toluene / 3.5 h / 88 °C / Inert atmosphere

With hydrogenchloride; thionyl chloride; hydrogen; 5%-palladium/activated carbon; N,N-dimethyl-formamide; In methanol; ethanol; tert-butyl methyl ether; water; toluene;