Technology Process of (1R,2R)-3-(3-hydroxyphenyl)-2-methyl-pentanoic acid
There total 8 articles about (1R,2R)-3-(3-hydroxyphenyl)-2-methyl-pentanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
5%-palladium/activated carbon;
In
methanol;
at 20 ℃;
for 15h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: diisobutylaluminium hydride / toluene / -10 - 0 °C / Inert atmosphere
1.2: 5 °C
2.1: carbon tetrabromide / 10.33 h / 62 °C / Inert atmosphere
3.1: triethylamine; lithium hexamethyldisilazane / toluene / 2.5 h / -65 °C / Inert atmosphere
3.2: 0.17 h / 20 - 30 °C
3.3: pH 1 - 2 / Cooling with ice
4.1: ethanol / 20 - 40 °C / Resolution of racemate; Reflux
5.1: hydrogenchloride / water; tert-butyl methyl ether / 0.25 h / 20 °C
6.1: hydrogen / 5%-palladium/activated carbon / methanol / 15 h / 20 °C
With
hydrogenchloride; hydrogen; diisobutylaluminium hydride; triethylamine; lithium hexamethyldisilazane;
carbon tetrabromide; 5%-palladium/activated carbon;
In
methanol; ethanol; tert-butyl methyl ether; water; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: ethanol / 20 - 40 °C / Resolution of racemate; Reflux
2: hydrogenchloride / water; tert-butyl methyl ether / 0.25 h / 20 °C
3: hydrogen / 5%-palladium/activated carbon / methanol / 15 h / 20 °C
With
hydrogenchloride; hydrogen;
5%-palladium/activated carbon;
In
methanol; ethanol; tert-butyl methyl ether; water;
