208836-69-5

Basic information

• Product Name: 3-(3'-benzyloxyphenyl)-(E)-propenoic acid ethyl ester
• Synonyms: 3-(3'-benzyloxyphenyl)-(E)-propenoic acid ethyl ester
• CAS NO: 208836-69-5
• Molecular Weight: 282.339
• Mol File: 208836-69-5.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 3-(3'-benzyloxyphenyl)-(E)-propenoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3'-benzyloxyphenyl)-(E)-propenoic acid ethyl ester(208836-69-5)
• EPA Substance Registry System: 3-(3'-benzyloxyphenyl)-(E)-propenoic acid ethyl ester(208836-69-5)

Safety Data

• Hazardous Substances Data: 208836-69-5(Hazardous Substances Data)

Upstream product

• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 1700-37-4 3-Benzyloxybenzaldehyde 
• 100-39-0 benzyl bromide 
• 96251-92-2 (E)-3-(3-hydroxyphenyl)acrylic acid ethyl ester 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 75849-10-4 ethyl 3-<3-(benzyloxy)phenyl>propanoate 
• 175591-09-0 tapentadol hydrochloride 
• 1384457-51-5 (αR,βR)-β-ethyl-3-hydroxy-N,N,α-trimethylbenzenepropanamide 
• 1384457-44-6 (2R,3R)-3-(3-benzyloxyphenyl)-2-methylpent-4-enoic acid 
• 1384457-45-7 (2R,3R)-3-(3-benzyloxyphenyl)-2-methylpent-4-enoic acid (R)-1-phenylethylamine salt 
• 1384457-52-6 (1R,2R)-3-(3-hydroxyphenyl)-2-methyl-pentanoic acid 
• 1384457-50-4 (2R,3R)-3-(3-hydroxyphenyl)-2-methylpentanoic acid chloride 
• 1384457-48-0 (2E)-3-(3-benzyloxyphenyl)prop-2-en-1-yl propionate 
• 438038-97-2 C₃₁H₃₁NO₅ 
• 155697-47-5 (S)-4-Benzyl-3-[(R)-3-(3-benzyloxy-phenyl)-4,4-difluoro-butyryl]-oxazolidin-2-one 
• 155697-48-6 (S)-4-Benzyl-3-[(S)-3-(3-benzyloxy-phenyl)-4,4-difluoro-butyryl]-oxazolidin-2-one 
• 155697-46-4 3-difluoromethyl-3-(3-benzyloxyphenyl)propionic acid 
• 155697-45-3 Acetic acid 3-(3-benzyloxy-phenyl)-4,4-difluoro-butyl ester 
• 155697-44-2 Acetic acid 3-(3-benzyloxy-phenyl)-pent-4-enyl ester 

Relevant articles and documents

5,6-dihydropyrrolo[2,1-a]isoquinolines as alternative of new drugs with cytotoxic activity

In this study, the pyrrolo[2,1-a]isoquinolines 4a–n were synthesized in good yields in a three steps synthesis from the corresponding α,β-unsaturated esters starting materials. These compounds were tested on six human cancer cells lines to measure the cyt

Wittig reactions in water media employing stabilized ylides with aldehydes. Synthesis of α,β-unsaturated esters from mixing aldehydes, α-bromoesters, and Ph3P in aqueous NaHCO3

(Chemical Equation Presented) Water is demonstrated to be an effective medium for the Wittig reaction over a wide range of stabilized ylides and aldehydes. Despite sometimes poor solubility of the reactants, good chemical yields normally ranging from 80 to 98% and high E-selectivities (up to 99%) are achieved, and the rate of the reactions in water is unexpectedly accelerated. The efficiency of water as a medium in the Wittig reaction is compared to conventional organic solvents ranging from carbon tetrachloride to methanol. The aqueous Wittig reaction works best when large hydrophobic entities are present, such as aromatic, heterocyclic aromatic carboxaldehydes, and long-chain aliphatic aldehydes with triphenylphosphoranes. The E/Z-isomeric ratio of the Wittig products appears dependent on the electron-accepting/donating capacity and the location of the substituents present in the aromatic ring. The effect of additives, such as benzoic acid, LiCl, and sodium dodecyl sulfate (SDS), on the Wittig reaction has been explored. The Wittig reaction can also be conducted in the presence of acidic entities, such as phenols and carboxylic acids. In addition, large α-substituents in the aliphatic aldehydes do not jeopardize the reaction. It is also demonstrated that hydrates of aldehydes can be used directly in the aqueous Wittig reaction as substrates. The scope of the aqueous Wittig reaction is extended to 24 examples of one-pot mixtures of Ph3P, α-bromoesters, and aldehydes in sodium bicarbonate solution (at 20°C for 40 min to 3 h) to provide Wittig products of up to 99% yield and up to 98% E-selectivity. Since water is inexpensive, extremely easy to handle, and represents no environmental concerns, it should be considered a possible medium for new organic reactions.

MEDICINAL COMPOSITIONS IMPROVED IN SOLUBLITY IN WATER

Solid dispersions are provided comprising an HER2 inhibitor which is hardly or not soluble in water and a hydrophilic polymer. These solid dispersions have been improved in the solubility of the HER2 inhibitor, oral absorption and bioavailability in blood