(2R,3R)-3-(3-benzyloxyphenyl)-2-methylpent-4-enoic acid (R)-1-phenylethylamine salt

Base Information

Chemical Name:(2R,3R)-3-(3-benzyloxyphenyl)-2-methylpent-4-enoic acid (R)-1-phenylethylamine salt
CAS No.:1384457-45-7
Molecular Formula:C₈H₁₁N*C₁₉H₂₀O₃
Molecular Weight:417.548
Hs Code.:

Synonyms:(2R,3R)-3-(3-benzyloxyphenyl)-2-methylpent-4-enoic acid (R)-1-phenylethylamine salt

Suppliers and Price of (2R,3R)-3-(3-benzyloxyphenyl)-2-methylpent-4-enoic acid (R)-1-phenylethylamine salt

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R)-3-(3-benzyloxyphenyl)-2-methylpent-4-enoic acid (R)-1-phenylethylamine salt

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2R,3R)-3-(3-benzyloxyphenyl)-2-methylpent-4-enoic acid (R)-1-phenylethylamine salt

There total 6 articles about (2R,3R)-3-(3-benzyloxyphenyl)-2-methylpent-4-enoic acid (R)-1-phenylethylamine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: (2RS,3RS)-3-(3-benzyloxyphenyl)-2-methylpent-4-enoic acid

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 1384457-45-7
(2R,3R)-3-(3-benzyloxyphenyl)-2-methylpent-4-enoic acid (R)-1-phenylethylamine salt

: (2S,3S)-3-(3-benzyloxyphenyl)-2-methylpent-4-enoic acid (R)-1-phenylethylamine salt

Guidance literature:: In ethanol; at 20 - 40 ℃; Resolution of racemate; Reflux;

Reference yield:

: 100-39-0
benzyl bromide

: 1384457-45-7
(2R,3R)-3-(3-benzyloxyphenyl)-2-methylpent-4-enoic acid (R)-1-phenylethylamine salt

: (2S,3S)-3-(3-benzyloxyphenyl)-2-methylpent-4-enoic acid (R)-1-phenylethylamine salt

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N-benzyl-N,N,N-triethylammonium chloride / N,N-dimethyl-formamide / 22 h / 80 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / toluene / -10 - 0 °C / Inert atmosphere

2.2: 5 °C

3.1: carbon tetrabromide / 10.33 h / 62 °C / Inert atmosphere

4.1: triethylamine; lithium hexamethyldisilazane / toluene / 2.5 h / -65 °C / Inert atmosphere

4.2: 0.17 h / 20 - 30 °C

4.3: pH 1 - 2 / Cooling with ice

5.1: ethanol / 20 - 40 °C / Resolution of racemate; Reflux

With diisobutylaluminium hydride; potassium carbonate; triethylamine; lithium hexamethyldisilazane; carbon tetrabromide; N-benzyl-N,N,N-triethylammonium chloride; In ethanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 96251-92-2
(E)-3-(3-hydroxyphenyl)acrylic acid ethyl ester

: 1384457-45-7
(2R,3R)-3-(3-benzyloxyphenyl)-2-methylpent-4-enoic acid (R)-1-phenylethylamine salt

: (2S,3S)-3-(3-benzyloxyphenyl)-2-methylpent-4-enoic acid (R)-1-phenylethylamine salt

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N-benzyl-N,N,N-triethylammonium chloride / N,N-dimethyl-formamide / 22 h / 80 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / toluene / -10 - 0 °C / Inert atmosphere

2.2: 5 °C

3.1: carbon tetrabromide / 10.33 h / 62 °C / Inert atmosphere

4.1: triethylamine; lithium hexamethyldisilazane / toluene / 2.5 h / -65 °C / Inert atmosphere

4.2: 0.17 h / 20 - 30 °C

4.3: pH 1 - 2 / Cooling with ice

5.1: ethanol / 20 - 40 °C / Resolution of racemate; Reflux

With diisobutylaluminium hydride; potassium carbonate; triethylamine; lithium hexamethyldisilazane; carbon tetrabromide; N-benzyl-N,N,N-triethylammonium chloride; In ethanol; N,N-dimethyl-formamide; toluene;