4-[6,7,bis(palmitoyloxy)-4-thiaoctanoylaminomethyl]benzoyl-glutamic acid di-t-butyl ester

Base Information

Chemical Name:4-[6,7,bis(palmitoyloxy)-4-thiaoctanoylaminomethyl]benzoyl-glutamic acid di-t-butyl ester
CAS No.:167767-58-0
Molecular Formula:C₆₀H₁₀₄N₂O₁₀S
Molecular Weight:1045.56
Hs Code.:

Synonyms:4-[6,7,bis(palmitoyloxy)-4-thiaoctanoylaminomethyl]benzoyl-glutamic acid di-t-butyl ester

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Chemical Property of 4-[6,7,bis(palmitoyloxy)-4-thiaoctanoylaminomethyl]benzoyl-glutamic acid di-t-butyl ester

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Technology Process of 4-[6,7,bis(palmitoyloxy)-4-thiaoctanoylaminomethyl]benzoyl-glutamic acid di-t-butyl ester

There total 7 articles about 4-[6,7,bis(palmitoyloxy)-4-thiaoctanoylaminomethyl]benzoyl-glutamic acid di-t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 4-(aminomethyl)benzoyl-glutamic acid di-t-butyl ester hydrochloride

: 144-55-8
sodium hydrogencarbonate

: 167768-15-2
6,7-dihydroxy-4-thiaoctanoic acid

: 112-67-4
n-hexadecanoyl chloride

: 167767-58-0
4-[6,7,bis(palmitoyloxy)-4-thiaoctanoylaminomethyl]benzoyl-glutamic acid di-t-butyl ester

Guidance literature:: With 2-(Dimethylamino)pyridine; triethylamine; citric acid; In N-methyl-acetamide; dichloromethane; ethyl acetate;

Reference yield:

: 32677-01-3
L-glutamic acid di-tert-butyl ester hydrochloride

: 167767-58-0
4-[6,7,bis(palmitoyloxy)-4-thiaoctanoylaminomethyl]benzoyl-glutamic acid di-t-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / DEPC, Et₃N / dimethylformamide / 1 h / Ambient temperature

2: 92 percent / H₂ / 10percent Pd/C / methanol

3: DEPC, Et₃N / dimethylformamide / Ambient temperature

4: DMAP / CH₂Cl₂

With dmap; hydrogen; triethylamine; diethyl dicarbonate; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.255

Reference yield:

: 162877-53-4
(S)-2-[4-(Benzyloxycarbonylamino-methyl)-benzoylamino]-pentanedioic acid di-tert-butyl ester

: 167767-58-0
4-[6,7,bis(palmitoyloxy)-4-thiaoctanoylaminomethyl]benzoyl-glutamic acid di-t-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / H₂ / 10percent Pd/C / methanol

2: DEPC, Et₃N / dimethylformamide / Ambient temperature

3: DMAP / CH₂Cl₂

With dmap; hydrogen; triethylamine; diethyl dicarbonate; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.255