(2E)-N-[4-(3-bromo-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]-4-(dimethylamino)-2-butenamide

Base Information

• Chemical Name: (2E)-N-[4-(3-bromo-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]-4-(dimethylamino)-2-butenamide
• CAS No.: 1245555-43-4
• Molecular Formula: C₁₉H₁₈BrFN₆O
• Molecular Weight: 445.294

Synonyms:(2E)-N-[4-(3-bromo-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]-4-(dimethylamino)-2-butenamide

Chemical Property of (2E)-N-[4-(3-bromo-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]-4-(dimethylamino)-2-butenamide

Chemical Property:

Purity/Quality:

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Technology Process of (2E)-N-[4-(3-bromo-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]-4-(dimethylamino)-2-butenamide

There total 2 articles about (2E)-N-[4-(3-bromo-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]-4-(dimethylamino)-2-butenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

dimethylaminoacetaldehyde diethyl acetal (3616-56-6) + diethyl 2-(4-(3-bromo-4-fluorophenylamino)pyrido[3,4-d]pyrimidin-6-ylamino)-2-oxoethylphosphonate (1245555-81-0) → (2E)-N-[4-(3-bromo-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]-4-(dimethylamino)-2-butenamide (1245555-43-4)

Guidance literature:

diethyl 2-(4-(3-bromo-4-fluorophenylamino)pyrido[3,4-d]pyrimidin-6-ylamino)-2-oxoethylphosphonate; With lithium chloride; In ISOPROPYLAMIDE; at 0 ℃; for 0.25h; Inert atmosphere of nitrogen;

With potassium hydroxide; In ISOPROPYLAMIDE; water; at 0 ℃; for 0.0333333h;

dimethylaminoacetaldehyde diethyl acetal; With hydrogenchloride; In ISOPROPYLAMIDE; water; at 0 ℃; Inert atmosphere of nitrogen;

Reference yield:

C17H12Br2FN5O + dimethyl amine (124-40-3) → (2E)-N-[4-(3-bromo-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]-4-(dimethylamino)-2-butenamide (1245555-43-4)

Guidance literature:

With triethylamine; In tetrahydrofuran; ISOPROPYLAMIDE; at 0 - 20 ℃;

Reference yield: 70.0%

2-(bromomethyl)-1-methyl-4-nitro-1H-imidazole (1245556-17-5) + (2E)-N-[4-(3-bromo-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]-4-(dimethylamino)-2-butenamide (1245555-43-4) → (2E)-4-{[4-(3-bromo-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]amino}-N,N-dimethyl-N-[(1-methyl-4-nitro-1H-imidazol-5-yl)methyl]-4-oxo-2-buten-1-ammonium bromide (1245555-46-7)

Guidance literature:

In 1-methyl-pyrrolidin-2-one; Inert atmosphere of nitrogen;

upstream raw materials:

dimethyl amine

dimethylaminoacetaldehyde diethyl acetal

diethyl 2-(4-(3-bromo-4-fluorophenylamino)pyrido[3,4-d]pyrimidin-6-ylamino)-2-oxoethylphosphonate

Downstream raw materials:

(2E)-4-{[4-(3-bromo-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]amino}-N,N-dimethyl-N-[(1-methyl-4-nitro-1H-imidazol-5-yl)methyl]-4-oxo-2-buten-1-ammonium bromide

(2E)-4-{[4-(3-bromo-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]amino}-N,N-dimethyl-N-{[1-methyl-4-nitro-2-(1-propynyl)-1H-imidazol-5-yl]methyl}-4-oxo-2-buten-1-ammonium bromide

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