Lenperone

Base Information

Chemical Name:Lenperone
CAS No.:24678-13-5
Molecular Formula:C22H23 F2 N O2
Molecular Weight:371.427
Hs Code.:2933399090
European Community (EC) Number:246-399-7
UNII:13P4GX22ES
DSSTox Substance ID:DTXSID7046120
Nikkaji Number:J19.939G
Wikipedia:Lenperone
Wikidata:Q6523202
NCI Thesaurus Code:C73287
Metabolomics Workbench ID:144654
ChEMBL ID:CHEMBL316004
Mol file:24678-13-5.mol

Synonyms:4'-fluoro-4-(4-(p-fluorobenozyl)piperidino)butyrophenone;AHR 2277;AHR-2277;lenperone;lenperone hydrochloride

Suppliers and Price of Lenperone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Lenperone
50mg
$ 460.00

TRC
Lenperone
50mg
$ 150.00

Medical Isotopes, Inc.
Lenperone
500 mg
$ 2200.00

American Custom Chemicals Corporation
LENPERONE 95.00%
500MG
$ 1963.50

American Custom Chemicals Corporation
LENPERONE 95.00%
50MG
$ 329.70

Total 14 raw suppliers

Chemical Property of Lenperone

Chemical Property:

Vapor Pressure:1.95E-10mmHg at 25°C
Boiling Point:507.9°Cat760mmHg
PKA:8.03±0.10(Predicted)
Flash Point:261°C
PSA：37.38000
Density:1.186g/cm³
LogP:4.46050
Storage Temp.:Refrigerator
Solubility.:Chloroform (Slightly), DMSO (Slightly)
XLogP3:4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:371.16968530
Heavy Atom Count:27
Complexity:489

Purity/Quality:

98%Min ^*data from raw suppliers

Lenperone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCC1C(=O)C2=CC=C(C=C2)F)CCCC(=O)C3=CC=C(C=C3)F
Uses Antipsy chotic. Lenperone is a neuroleptic butyrophenone. Lenperone is an effective atypical antipsychotic drug used in the treatment of schizophrenia.

Technology Process of Lenperone

There total 6 articles about Lenperone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 56346-57-7
(4-fluorophenyl)-piperidin-4-ylmethanone

: 40132-01-2
1-(4-fluorophenyl)-4-bromo-1-butanone

: 24678-13-5
lenperone

Guidance literature:: With potassium carbonate; potassium iodide; In toluene; at 125 ℃; for 24h;
DOI:10.1039/d0gc00383b

Reference yield: 62.0%

: 4-(4-fluorobenzyl)-1-(4-(4-fluorophenyl)butyl)piperidine

: 24678-13-5
lenperone

Guidance literature:: With tert.-butylnitrite; N-hydroxyphthalimide; In acetonitrile; at 90 ℃; for 36h; Schlenk technique;

Reference yield:

: 89326-70-5
1-bromo-4-(4-fluorophenyl)-butane

: 92822-02-1
4-(4-fluorobenzyl)piperidine

: 24678-13-5
lenperone

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate; potassium iodide / acetonitrile / 18 h / Reflux

2.1: trifluoroacetic acid / 0.08 h / Sealed tube

2.2: 120 h / 20 °C

With potassium carbonate; trifluoroacetic acid; potassium iodide; In acetonitrile;
DOI:10.1021/acs.orglett.6b02003