2-[[5-bromo-2-(3-chloro-2-pyridyl)pyrazole-3-carbonyl]amino]-5-cyano-3-methyl-benzoic acid

Base Information

Chemical Name:2-[[5-bromo-2-(3-chloro-2-pyridyl)pyrazole-3-carbonyl]amino]-5-cyano-3-methyl-benzoic acid
CAS No.:1456712-16-5
Molecular Formula:C₁₈H₁₁BrClN₅O₃
Molecular Weight:460.674
Hs Code.:

Synonyms:2-[[5-bromo-2-(3-chloro-2-pyridyl)pyrazole-3-carbonyl]amino]-5-cyano-3-methyl-benzoic acid

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Chemical Property of 2-[[5-bromo-2-(3-chloro-2-pyridyl)pyrazole-3-carbonyl]amino]-5-cyano-3-methyl-benzoic acid

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Technology Process of 2-[[5-bromo-2-(3-chloro-2-pyridyl)pyrazole-3-carbonyl]amino]-5-cyano-3-methyl-benzoic acid

There total 1 articles about 2-[[5-bromo-2-(3-chloro-2-pyridyl)pyrazole-3-carbonyl]amino]-5-cyano-3-methyl-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 871239-18-8
2-amino-5-cyano-3-methyl-benzoic acid

: 943982-60-3
3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carbonyl chloride

: 1456712-16-5
2-[[5-bromo-2-(3-chloro-2-pyridyl)pyrazole-3-carbonyl]amino]-5-cyano-3-methyl-benzoic acid

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 18h; Inert atmosphere;

Reference yield: 77.67%

: 1456712-16-5
2-[[5-bromo-2-(3-chloro-2-pyridyl)pyrazole-3-carbonyl]amino]-5-cyano-3-methyl-benzoic acid

: 95034-05-2
tert-butyl (2-amino-2-methylpropyl)carbamate

: tert-butyl (2-((2-(3-bromo-1-(3-chloro-2-pyridyl)-1H-pyrazole-5-carboxamido)-5-cyano-3-methylbenzamido))-2-methylpropionate)

Guidance literature:: With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; Cooling with ice;

Reference yield: 49.0%

: 67-56-1
methanol

: 1456712-16-5
2-[[5-bromo-2-(3-chloro-2-pyridyl)pyrazole-3-carbonyl]amino]-5-cyano-3-methyl-benzoic acid

: 1359859-25-8
methyl 2-[[5-bromo-2-(3-chloro-2-pyridyl)pyrazole-3-carbonyl]amino]-5-cyano-3-methyl-benzoate

Guidance literature:: 2-[[5-bromo-2-(3-chloro-2-pyridyl)pyrazole-3-carbonyl]amino]-5-cyano-3-methyl-benzoic acid; With thionyl chloride; In toluene; for 18h; Inert atmosphere; Reflux;

methanol; With triethylamine; for 4h; Reflux;