3-(2-chloro-4-((cyclohexylmethyl)oxy)benzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylic acid

Base Information

Chemical Name:3-(2-chloro-4-((cyclohexylmethyl)oxy)benzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylic acid
CAS No.:219764-81-5
Molecular Formula:C₂₂H₂₄ClN₃O₃
Molecular Weight:413.904
Hs Code.:

Synonyms:3-(2-chloro-4-((cyclohexylmethyl)oxy)benzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylic acid

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Chemical Property of 3-(2-chloro-4-((cyclohexylmethyl)oxy)benzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylic acid

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Technology Process of 3-(2-chloro-4-((cyclohexylmethyl)oxy)benzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylic acid

There total 16 articles about 3-(2-chloro-4-((cyclohexylmethyl)oxy)benzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 27048-04-0
2-amino-6-chloro-3-nitropyridine

: 219764-81-5
3-(2-chloro-4-((cyclohexylmethyl)oxy)benzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogen bromide / acetic acid / 13 h / 90 - 100 °C

4: 1,3-bis-(diphenylphosphino)propane; triethylamine / palladium diacetate / DMF (N,N-dimethyl-formamide) / 14 h / 85 °C / 7600.51 Torr

With 1,3-bis-(diphenylphosphino)propane; hydrogen bromide; triethylamine; palladium diacetate; In DMF (N,N-dimethyl-formamide); acetic acid;

Reference yield:

: 55304-80-8
2,6-dibromo-3-nitropyridine

: 219764-81-5
3-(2-chloro-4-((cyclohexylmethyl)oxy)benzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: ammonia / ethanol / 19 h / 20 °C

2: sulfuric acid / acetic acid / 0.67 h / 65 °C

4: 1,3-bis-(diphenylphosphino)propane; triethylamine / palladium diacetate / DMF (N,N-dimethyl-formamide) / 14 h / 85 °C / 7600.51 Torr

With sulfuric acid; 1,3-bis-(diphenylphosphino)propane; ammonia; triethylamine; palladium diacetate; In DMF (N,N-dimethyl-formamide); ethanol; acetic acid;

Reference yield:

: 84487-04-7
6-bromo-3-nitro-pyridin-2-ylamine

: 219764-81-5
3-(2-chloro-4-((cyclohexylmethyl)oxy)benzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride; iron / ethanol; water / 2 h / 20 °C / Heating / reflux

2: acetic acid / 29 h / Heating / reflux

3: 1,3-bis-(diphenylphosphino)propane; triethylamine / palladium diacetate / DMF (N,N-dimethyl-formamide) / 14 h / 85 °C / 7600.51 Torr

With hydrogenchloride; 1,3-bis-(diphenylphosphino)propane; iron; triethylamine; palladium diacetate; In DMF (N,N-dimethyl-formamide); ethanol; water; acetic acid;