methyl 1-({[5-(2-methoxyphenyl)-1-naphthalen-1-yl-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylate

Base Information

Chemical Name:methyl 1-({[5-(2-methoxyphenyl)-1-naphthalen-1-yl-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylate
CAS No.:1612148-92-1
Molecular Formula:C₂₉H₂₉N₃O₄
Molecular Weight:483.567
Hs Code.:

Synonyms:methyl 1-({[5-(2-methoxyphenyl)-1-naphthalen-1-yl-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylate

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Chemical Property of methyl 1-({[5-(2-methoxyphenyl)-1-naphthalen-1-yl-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylate

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Technology Process of methyl 1-({[5-(2-methoxyphenyl)-1-naphthalen-1-yl-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylate

There total 5 articles about methyl 1-({[5-(2-methoxyphenyl)-1-naphthalen-1-yl-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1612148-84-1
5-(2-methoxyphenyl)-1-naphthalen-1-yl-1H-pyrazole-3-carboxylic acid

: 37993-32-1
1-amino-cyclohexanecarboxylic acid methyl ester hydrochloride

: 1612148-92-1
methyl 1-({[5-(2-methoxyphenyl)-1-naphthalen-1-yl-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylate

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jm5003843

Reference yield: 73.0%

: 1612148-92-1
methyl 1-({[5-(2-methoxyphenyl)-1-naphthalen-1-yl-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylate

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane; for 16h; Inert atmosphere;

Reference yield:

: 1612148-77-2
methyl 5-(2-methoxyphenyl)-1-naphthalen-1-yl-1H-pyrazole-3-carboxylate

: 1612148-92-1
methyl 1-({[5-(2-methoxyphenyl)-1-naphthalen-1-yl-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide / 1,4-dioxane / 16 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 16 h / 20 °C / Inert atmosphere

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; lithium hydroxide; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm5003843