tert-butyl dimethyl(2-methyl-4-(((4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methyl)thio)phenoxy)silane

Base Information

Chemical Name:tert-butyl dimethyl(2-methyl-4-(((4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methyl)thio)phenoxy)silane
CAS No.:1030367-80-6
Molecular Formula:C₂₇H₃₁F₃OSSi
Molecular Weight:488.689
Hs Code.:

Synonyms:tert-butyl dimethyl(2-methyl-4-(((4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methyl)thio)phenoxy)silane

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Chemical Property of tert-butyl dimethyl(2-methyl-4-(((4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methyl)thio)phenoxy)silane

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Technology Process of tert-butyl dimethyl(2-methyl-4-(((4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methyl)thio)phenoxy)silane

There total 3 articles about tert-butyl dimethyl(2-methyl-4-(((4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methyl)thio)phenoxy)silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1030367-79-3
2-methyl-4-(((4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methyl)thio)phenol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1030367-80-6
tert-butyl dimethyl(2-methyl-4-(((4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methyl)thio)phenoxy)silane

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

: 454464-38-1
4-Chloromethyl-4'-trifluoromethyl-biphenyl

: 1030367-80-6
tert-butyl dimethyl(2-methyl-4-(((4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methyl)thio)phenoxy)silane

Guidance literature:: Multi-step reaction with 2 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

1.2: 0.17 h / -78 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 4 h / 25 °C

With 1H-imidazole; isopropylmagnesium chloride; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 457889-46-2
(4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methanol

: 1030367-80-6
tert-butyl dimethyl(2-methyl-4-(((4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methyl)thio)phenoxy)silane

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

2: caesium carbonate / acetonitrile / 12 h / 20 °C / Inert atmosphere

3: 1H-imidazole / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

With 1H-imidazole; thionyl chloride; caesium carbonate; N,N-dimethyl-formamide; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2018.06.044