2-methyl-4-(((4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methyl)thio)phenol

Base Information

Chemical Name:2-methyl-4-(((4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methyl)thio)phenol
CAS No.:1030367-79-3
Molecular Formula:C₂₁H₁₇F₃OS
Molecular Weight:374.427
Hs Code.:

Synonyms:2-methyl-4-(((4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methyl)thio)phenol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-methyl-4-(((4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methyl)thio)phenol

Chemical Property:

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Technology Process of 2-methyl-4-(((4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methyl)thio)phenol

There total 3 articles about 2-methyl-4-(((4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methyl)thio)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 454464-38-1
4-Chloromethyl-4'-trifluoromethyl-biphenyl

: 60577-30-2
4-iodo-2-methyl-phenol

: 1030367-79-3
2-methyl-4-(((4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methyl)thio)phenol

Guidance literature:: 4-iodo-2-methyl-phenol; With isopropylmagnesium chloride; In tetrahydrofuran; at 0 ℃; for 0.166667h;

With tert.-butyl lithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h;

4-Chloromethyl-4'-trifluoromethyl-biphenyl; With ammonium chloride; sulfur; more than 3 stages;

Reference yield: 72.0%

: 454464-38-1
4-Chloromethyl-4'-trifluoromethyl-biphenyl

: 32281-01-9
4-mercapto-2-methylphenol

: 1030367-79-3
2-methyl-4-(((4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methyl)thio)phenol

Guidance literature:: With caesium carbonate; In acetonitrile; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.bmc.2018.06.044

Reference yield:

: 457889-46-2
(4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methanol

: 1030367-79-3
2-methyl-4-(((4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methyl)thio)phenol

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

2: caesium carbonate / acetonitrile / 12 h / 20 °C / Inert atmosphere

With thionyl chloride; caesium carbonate; N,N-dimethyl-formamide; In dichloromethane; acetonitrile;
DOI:10.1016/j.bmc.2018.06.044