4,4-[1,3-propanediylbis(oxy)]bisbenzeneacetonitrile

Base Information

Chemical Name:4,4-[1,3-propanediylbis(oxy)]bisbenzeneacetonitrile
CAS No.:855926-42-0
Molecular Formula:C₁₉H₁₈N₂O₂
Molecular Weight:306.364
Hs Code.:

Synonyms:4,4-[1,3-propanediylbis(oxy)]bisbenzeneacetonitrile

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Chemical Property of 4,4-[1,3-propanediylbis(oxy)]bisbenzeneacetonitrile

Chemical Property:

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Technology Process of 4,4-[1,3-propanediylbis(oxy)]bisbenzeneacetonitrile

There total 7 articles about 4,4-[1,3-propanediylbis(oxy)]bisbenzeneacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 773837-37-9
sodium cyanide

: 93408-26-5
4,4-[1,3-propanediylbis(oxy)]bisbenzyl chloride

: 855926-42-0
4,4-[1,3-propanediylbis(oxy)]bisbenzeneacetonitrile

Guidance literature:: In N,N-dimethyl-formamide; at 100 ℃; for 5h;
DOI:10.1021/acsmedchemlett.8b00389

Reference yield:

: 14191-95-8
4-cyanomethylphenol

: 109-64-8
1,3-dibromo-propane

: 855926-42-0
4,4-[1,3-propanediylbis(oxy)]bisbenzeneacetonitrile

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 4h;
DOI:10.1080/15421400490425847

Reference yield:

: 3722-80-3
1,3-bis(4-formylphenoxy)propane

: 855926-42-0
4,4-[1,3-propanediylbis(oxy)]bisbenzeneacetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate / methanol; tetrahydrofuran / 6 h / 0 - 20 °C

2: thionyl chloride / dichloromethane / 5 h / 0 °C / Inert atmosphere; Reflux

3: N,N-dimethyl-formamide / 5 h / 100 °C

With sodium tetrahydroborate; thionyl chloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/acsmedchemlett.8b00389