methanesulfonic acid 2-[(tert-butyl-diphenyl-silanyloxy)-phenyl-methyl]-benzyl ester

Base Information

• Chemical Name: methanesulfonic acid 2-[(tert-butyl-diphenyl-silanyloxy)-phenyl-methyl]-benzyl ester
• CAS No.: 244254-87-3
• Molecular Formula: C₃₁H₃₄O₄SSi
• Molecular Weight: 530.76
• Mol file: 244254-87-3.mol

Synonyms:methanesulfonic acid 2-[(tert-butyl-diphenyl-silanyloxy)-phenyl-methyl]-benzyl ester

Chemical Property of methanesulfonic acid 2-[(tert-butyl-diphenyl-silanyloxy)-phenyl-methyl]-benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methanesulfonic acid 2-[(tert-butyl-diphenyl-silanyloxy)-phenyl-methyl]-benzyl ester

There total 5 articles about methanesulfonic acid 2-[(tert-butyl-diphenyl-silanyloxy)-phenyl-methyl]-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methanesulfonyl chloride (124-63-0) + {2-[(tert-butyl-diphenyl-silanyloxy)-phenyl-methyl]-phenyl}-methanol (244254-86-2) → methanesulfonic acid 2-[(tert-butyl-diphenyl-silanyloxy)-phenyl-methyl]-benzyl ester (244254-87-3)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃;

DOI:10.1016/S0957-4166(99)00231-1

Reference yield:

methyl o-benzoylbenzoate (606-28-0) → methanesulfonic acid 2-[(tert-butyl-diphenyl-silanyloxy)-phenyl-methyl]-benzyl ester (244254-87-3)

Guidance literature:

Multi-step reaction with 5 steps

1: LiAlH₄ / diethyl ether

2: 30 percent / 1,3-dicyclohexylcarbodiimide; 4-dimethylaminopyridine / CH₂Cl₂ / 48 h / 20 °C

3: 97 percent / imidazole / dimethylformamide / 20 °C

4: 81 percent / K₂CO₃ / methanol / 20 °C

5: 97 percent / Et₃N / CH₂Cl₂ / 0 °C

With 1H-imidazole; dmap; lithium aluminium tetrahydride; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0957-4166(99)00231-1

Reference yield:

(2-hydroxymethylphenyl)phenylmethanol (1586-01-2) → methanesulfonic acid 2-[(tert-butyl-diphenyl-silanyloxy)-phenyl-methyl]-benzyl ester (244254-87-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 30 percent / 1,3-dicyclohexylcarbodiimide; 4-dimethylaminopyridine / CH₂Cl₂ / 48 h / 20 °C

2: 97 percent / imidazole / dimethylformamide / 20 °C

3: 81 percent / K₂CO₃ / methanol / 20 °C

4: 97 percent / Et₃N / CH₂Cl₂ / 0 °C

With 1H-imidazole; dmap; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0957-4166(99)00231-1

upstream raw materials:

methanesulfonyl chloride

{2-[(tert-butyl-diphenyl-silanyloxy)-phenyl-methyl]-phenyl}-methanol

methyl o-benzoylbenzoate

(2-hydroxymethylphenyl)phenylmethanol

Downstream raw materials:

(R)-o-methylbenzhydrol

tert-butyl-diphenyl-(phenyl-o-tolyl-methoxy)-silane