3-amino-N-[2-chloro-5-(2-methoxyethyl)benzyl]-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}butanamide

Base Information

Chemical Name:3-amino-N-[2-chloro-5-(2-methoxyethyl)benzyl]-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}butanamide
CAS No.:921629-19-8
Molecular Formula:C₃₃H₃₉Cl₃N₂O₄
Molecular Weight:634.043
Hs Code.:

Synonyms:3-amino-N-[2-chloro-5-(2-methoxyethyl)benzyl]-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}butanamide

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Chemical Property of 3-amino-N-[2-chloro-5-(2-methoxyethyl)benzyl]-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}butanamide

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Technology Process of 3-amino-N-[2-chloro-5-(2-methoxyethyl)benzyl]-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}butanamide

There total 11 articles about 3-amino-N-[2-chloro-5-(2-methoxyethyl)benzyl]-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1056555-48-6
N-[2-chloro-5-(2-methoxyethyl)benzyl]-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxobutanamide

: 921629-19-8
3-amino-N-[2-chloro-5-(2-methoxyethyl)benzyl]-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}butanamide

Guidance literature:: N-[2-chloro-5-(2-methoxyethyl)benzyl]-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxobutanamide; With ammonium acetate; sodium cyanoborohydride; In methanol; for 2h; Heating / reflux;

With sodium hydroxide; water; In ethyl acetate;

Reference yield:

: 2432-12-4
2,6-dichloro-4-methylophenol

: 921629-19-8
3-amino-N-[2-chloro-5-(2-methoxyethyl)benzyl]-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}butanamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: 1H-imidazole / 4 h / 150 °C

2.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran; toluene / 4 h / 80 °C

3.1: sodium tetrahydroborate / methanol / 0.75 h / 0 - 20 °C

4.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 1.75 h / 0 - 20 °C

5.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.5 h / -78 - -40 °C

5.2: 15.25 h / -78 - 20 °C

6.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0.5 h / 20 °C

7.1: methanol; lithium hydroxide; water / 12 h / 20 °C

7.2: pH ~ 2

8.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

9.1: Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C

10.1: ammonium acetate; sodium cyanoborohydride / methanol / 2 h / Heating / reflux

With 1H-imidazole; methanol; lithium hydroxide; sodium tetrahydroborate; tributylphosphine; ammonium acetate; water; iodine; potassium hexamethylsilazane; sodium cyanoborohydride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 921630-64-0
2-(2,6-dichloro-4-methyl-phenoxy)-ethanol

: 921629-19-8
3-amino-N-[2-chloro-5-(2-methoxyethyl)benzyl]-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}butanamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran; toluene / 4 h / 80 °C

2.1: sodium tetrahydroborate / methanol / 0.75 h / 0 - 20 °C

3.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 1.75 h / 0 - 20 °C

4.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.5 h / -78 - -40 °C

4.2: 15.25 h / -78 - 20 °C

5.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0.5 h / 20 °C

6.1: methanol; lithium hydroxide; water / 12 h / 20 °C

6.2: pH ~ 2

7.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

8.1: Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C

9.1: ammonium acetate; sodium cyanoborohydride / methanol / 2 h / Heating / reflux

With 1H-imidazole; methanol; lithium hydroxide; sodium tetrahydroborate; tributylphosphine; ammonium acetate; water; iodine; potassium hexamethylsilazane; sodium cyanoborohydride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;