N-[2-chloro-5-(2-methoxyethyl)benzyl]-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxobutanamide

Base Information

Chemical Name:N-[2-chloro-5-(2-methoxyethyl)benzyl]-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxobutanamide
CAS No.:1056555-48-6
Molecular Formula:C₃₃H₃₆Cl₃NO₅
Molecular Weight:633.012
Hs Code.:

Synonyms:N-[2-chloro-5-(2-methoxyethyl)benzyl]-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxobutanamide

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Chemical Property of N-[2-chloro-5-(2-methoxyethyl)benzyl]-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxobutanamide

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Technology Process of N-[2-chloro-5-(2-methoxyethyl)benzyl]-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxobutanamide

There total 10 articles about N-[2-chloro-5-(2-methoxyethyl)benzyl]-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxobutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1056555-53-3
N-[2-chloro-5-(2-methoxyethyl)benzyl]-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-hydroxybutanamide

: 1056555-48-6
N-[2-chloro-5-(2-methoxyethyl)benzyl]-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxobutanamide

Guidance literature:: N-[2-chloro-5-(2-methoxyethyl)benzyl]-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-hydroxybutanamide; With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; for 2h;

With sodium hydrogencarbonate; In methanol; diethyl ether; dichloromethane; water;

Reference yield:

: 921630-64-0
2-(2,6-dichloro-4-methyl-phenoxy)-ethanol

: 1056555-48-6
N-[2-chloro-5-(2-methoxyethyl)benzyl]-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxobutanamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran; toluene / 4 h / 80 °C

2.1: sodium tetrahydroborate / methanol / 0.75 h / 0 - 20 °C

3.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 1.75 h / 0 - 20 °C

4.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.5 h / -78 - -40 °C

4.2: 15.25 h / -78 - 20 °C

5.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0.5 h / 20 °C

6.1: methanol; lithium hydroxide; water / 12 h / 20 °C

6.2: pH ~ 2

7.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

8.1: Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C

With 1H-imidazole; methanol; lithium hydroxide; sodium tetrahydroborate; tributylphosphine; water; iodine; potassium hexamethylsilazane; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 921630-61-7
4-[2-(2,6-dichloro-4-methyl-phenoxy)-ethoxy]-benzaldehyde

: 1056555-48-6
N-[2-chloro-5-(2-methoxyethyl)benzyl]-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxobutanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium tetrahydroborate / methanol / 0.75 h / 0 - 20 °C

2.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 1.75 h / 0 - 20 °C

3.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.5 h / -78 - -40 °C

3.2: 15.25 h / -78 - 20 °C

4.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0.5 h / 20 °C

5.1: methanol; lithium hydroxide; water / 12 h / 20 °C

5.2: pH ~ 2

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

7.1: Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C

With 1H-imidazole; methanol; lithium hydroxide; sodium tetrahydroborate; water; iodine; potassium hexamethylsilazane; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;