Octadecanoic acid ((E)-(1S,2R)-2-benzyloxy-1-hydroxymethyl-heptadec-3-enyl)-amide

Base Information

• Chemical Name: Octadecanoic acid ((E)-(1S,2R)-2-benzyloxy-1-hydroxymethyl-heptadec-3-enyl)-amide
• CAS No.: 201139-02-8
• Molecular Formula: C₄₃H₇₇NO₃
• Molecular Weight: 656.089
• Mol file: 201139-02-8.mol

Synonyms:Octadecanoic acid ((E)-(1S,2R)-2-benzyloxy-1-hydroxymethyl-heptadec-3-enyl)-amide

Chemical Property of Octadecanoic acid ((E)-(1S,2R)-2-benzyloxy-1-hydroxymethyl-heptadec-3-enyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Octadecanoic acid ((E)-(1S,2R)-2-benzyloxy-1-hydroxymethyl-heptadec-3-enyl)-amide

There total 1 articles about Octadecanoic acid ((E)-(1S,2R)-2-benzyloxy-1-hydroxymethyl-heptadec-3-enyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

Stearoyl chloride (112-76-5) + (E)-(2S,3R)-2-Amino-3-benzyloxy-octadec-4-en-1-ol (850223-35-7) → Octadecanoic acid ((E)-(1S,2R)-2-benzyloxy-1-hydroxymethyl-heptadec-3-enyl)-amide (201139-02-8)

Guidance literature:

With sodium acetate; In tetrahydrofuran; for 0.5h;

DOI:10.1016/S0040-4039(97)10365-3

Reference yield: 74.0%

Octadecanoic acid ((E)-(1S,2R)-2-benzyloxy-1-hydroxymethyl-heptadec-3-enyl)-amide (201139-02-8) + C33H40ClN2O9P (201139-12-0) → Benzoic acid (2R,3R,4S,5R,6R)-4-benzyloxy-6-benzyloxymethyl-2-((E)-(2S,3R)-3-benzyloxy-2-octadecanoylamino-octadec-4-enyloxy)-5-(2-chloro-acetoxy)-tetrahydro-pyran-3-yl ester (201139-13-1)

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1016/S0040-4039(97)10365-3

Reference yield: 22.0%

C92H103N2O17P + Octadecanoic acid ((E)-(1S,2R)-2-benzyloxy-1-hydroxymethyl-heptadec-3-enyl)-amide (201139-02-8) → C97H121NO19 + C131H155NO24 + Octadecanoic acid [(E)-(1S,2R)-2-benzyloxy-1-((2S,3R,4S,5S,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxymethyl)-heptadec-3-enyl]-amide

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1016/S0040-4039(97)10365-3

upstream raw materials:

Stearoyl chloride

(E)-(2S,3R)-2-Amino-3-benzyloxy-octadec-4-en-1-ol

Downstream raw materials:

Benzoic acid (2R,3R,4S,5R,6R)-4-benzyloxy-6-benzyloxymethyl-2-((E)-(2S,3R)-3-benzyloxy-2-octadecanoylamino-octadec-4-enyloxy)-5-(2-chloro-acetoxy)-tetrahydro-pyran-3-yl ester

Benzoic acid (2R,3R,4S,5R,6R)-4-benzyloxy-6-benzyloxymethyl-2-((E)-(2S,3R)-3-benzyloxy-2-octadecanoylamino-octadec-4-enyloxy)-5-hydroxy-tetrahydro-pyran-3-yl ester