C₈H₇N₃O₃

Base Information

• Chemical Name: C₈H₇N₃O₃
• CAS No.: 1373496-72-0
• Molecular Formula: C₈H₇N₃O₃
• Molecular Weight: 193.162
• Mol file: 1373496-72-0.mol

Synonyms:C₈H₇N₃O₃

Chemical Property of C₈H₇N₃O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₈H₇N₃O₃

There total 3 articles about C₈H₇N₃O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

C10H11N3O3 (1373496-68-4) → C8H7N3O3 (1373496-72-0)

Guidance literature:

C₁₀H₁₁N₃O₃; With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 20 ℃; for 12h; Inert atmosphere;

With hydrogenchloride; In water; pH=4;

DOI:10.1021/jo300063u

Reference yield:

2-azidophenol (24541-44-4) → C8H7N3O3 (1373496-72-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

2.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 12 h / 20 °C / Inert atmosphere

2.2: pH 4

With lithium hydroxide monohydrate; potassium carbonate; potassium iodide; In tetrahydrofuran; water; N,N-dimethyl-formamide;

DOI:10.1021/jo300063u

Reference yield:

2-amino-phenol (95-55-6) → C8H7N3O3 (1373496-72-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.08 h / -5 - -3 °C / Inert atmosphere

1.2: Inert atmosphere

1.3: 2 h / 0 °C / Inert atmosphere

2.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

3.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 12 h / 20 °C / Inert atmosphere

3.2: pH 4

With hydrogenchloride; lithium hydroxide monohydrate; potassium carbonate; potassium iodide; sodium nitrite; In tetrahydrofuran; water; N,N-dimethyl-formamide;

DOI:10.1021/jo300063u

upstream raw materials:

C₁₀H₁₁N₃O₃

2-azidophenol

2-amino-phenol

Downstream raw materials:

C₂₃H₂₇N₅O₄

C₂₄H₂₉N₅O₄

C₉H₁₀N₄O₂

C₁₀H₁₂N₄O₂