5-chloro-2-{2-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-2-oxo-ethoxy}-benzaldehyde

Base Information

Chemical Name:5-chloro-2-{2-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-2-oxo-ethoxy}-benzaldehyde
CAS No.:217645-80-2
Molecular Formula:C₂₂H₂₄ClFN₂O₃
Molecular Weight:418.896
Hs Code.:

Synonyms:5-chloro-2-{2-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-2-oxo-ethoxy}-benzaldehyde

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Chemical Property of 5-chloro-2-{2-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-2-oxo-ethoxy}-benzaldehyde

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Technology Process of 5-chloro-2-{2-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-2-oxo-ethoxy}-benzaldehyde

There total 6 articles about 5-chloro-2-{2-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-2-oxo-ethoxy}-benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 217648-11-8
2-chloro-1-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-ethanone

: 635-93-8
5-chlorosalicyclaldehyde

: 217645-80-2
5-chloro-2-{2-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-2-oxo-ethoxy}-benzaldehyde

Guidance literature:: With N,N-dimethyl acetamide; potassium carbonate; In toluene; at 85 ℃; for 12 - 13h;

Reference yield:

: 352-11-4
1-chloromethyl-4-fluorobenzene

: 217645-80-2
5-chloro-2-{2-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-2-oxo-ethoxy}-benzaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: tetrabutylammomium bromide; sodium hydroxide / cyclohexane; water / 6 h / 35 - 45 °C / Inert atmosphere

2: methanol / 1 h / 60 - 70 °C / Inert atmosphere

3: sodium hydroxide / water; 2-methyltetrahydrofuran / 0.92 h / 20 - 25 °C / Inert atmosphere

4: potassium carbonate; potassium iodide / 10 h / 66 - 70 °C / Inert atmosphere

With tetrabutylammomium bromide; potassium carbonate; potassium iodide; sodium hydroxide; In 2-methyltetrahydrofuran; methanol; cyclohexane; water;
DOI:10.1021/op7000386

Reference yield:

: 364066-92-2
(2S,5R)-1-(4-fluorobenzyl)-2,5-dimethylpiperazine

: 217645-80-2
5-chloro-2-{2-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-2-oxo-ethoxy}-benzaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: methanol / 1 h / 60 - 70 °C / Inert atmosphere

2: sodium hydroxide / water; 2-methyltetrahydrofuran / 0.92 h / 20 - 25 °C / Inert atmosphere

3: potassium carbonate; potassium iodide / 10 h / 66 - 70 °C / Inert atmosphere

With potassium carbonate; potassium iodide; sodium hydroxide; In 2-methyltetrahydrofuran; methanol; water;
DOI:10.1021/op7000386