(2S)-(5-allyl-4-tert-butyldimethylsilyloxy-3,6-dihydro-2H-pyran-2-yl)methyl benzoate

Base Information

Chemical Name:(2S)-(5-allyl-4-tert-butyldimethylsilyloxy-3,6-dihydro-2H-pyran-2-yl)methyl benzoate
CAS No.:1451079-87-0
Molecular Formula:C₂₂H₃₂O₄Si
Molecular Weight:388.579
Hs Code.:

Synonyms:(2S)-(5-allyl-4-tert-butyldimethylsilyloxy-3,6-dihydro-2H-pyran-2-yl)methyl benzoate

Suppliers and Price of (2S)-(5-allyl-4-tert-butyldimethylsilyloxy-3,6-dihydro-2H-pyran-2-yl)methyl benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S)-(5-allyl-4-tert-butyldimethylsilyloxy-3,6-dihydro-2H-pyran-2-yl)methyl benzoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S)-(5-allyl-4-tert-butyldimethylsilyloxy-3,6-dihydro-2H-pyran-2-yl)methyl benzoate

There total 4 articles about (2S)-(5-allyl-4-tert-butyldimethylsilyloxy-3,6-dihydro-2H-pyran-2-yl)methyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1451079-79-0
(2S)-(5-allyl-4-tert-butyldimethylsilyloxy-3,6-dihydro-2H-pyran-2-yl)methanol

: 98-88-4
benzoyl chloride

: 1451079-87-0
(2S)-(5-allyl-4-tert-butyldimethylsilyloxy-3,6-dihydro-2H-pyran-2-yl)methyl benzoate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 24h;
DOI:10.1016/j.tet.2013.07.048

Reference yield:

: 52358-87-9
3-methylenehex-5-en-2-one

: 1451079-87-0
(2S)-(5-allyl-4-tert-butyldimethylsilyloxy-3,6-dihydro-2H-pyran-2-yl)methyl benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

1.2: 0.5 h / -78 °C / Inert atmosphere

2.1: (S)-6,6'-dibromo-1,1'-bi-2-naphthol; titanium(IV) isopropylate / toluene / 5.08 h / 0 - 20 °C

3.1: lithium aluminium tetrahydride / diethyl ether / 0.17 h / 0 °C

4.1: triethylamine; dmap / dichloromethane / 24 h / 0 - 20 °C

With titanium(IV) isopropylate; dmap; lithium aluminium tetrahydride; potassium tert-butylate; (S)-6,6'-dibromo-1,1'-bi-2-naphthol; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; toluene;
DOI:10.1016/j.tet.2013.07.048

Reference yield:

: 1451079-76-7
2-tert-butyldimethylsilyloxy-3-methylenehexa-1,5-diene

: 1451079-87-0
(2S)-(5-allyl-4-tert-butyldimethylsilyloxy-3,6-dihydro-2H-pyran-2-yl)methyl benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: (S)-6,6'-dibromo-1,1'-bi-2-naphthol; titanium(IV) isopropylate / toluene / 5.08 h / 0 - 20 °C

2: lithium aluminium tetrahydride / diethyl ether / 0.17 h / 0 °C

3: triethylamine; dmap / dichloromethane / 24 h / 0 - 20 °C

With titanium(IV) isopropylate; dmap; lithium aluminium tetrahydride; (S)-6,6'-dibromo-1,1'-bi-2-naphthol; triethylamine; In diethyl ether; dichloromethane; toluene;
DOI:10.1016/j.tet.2013.07.048