2,2-difluoro-3-hydroxy-3-(4-nitro-benzoylamino)-propionic acid ethyl ester

Base Information

• Chemical Name: 2,2-difluoro-3-hydroxy-3-(4-nitro-benzoylamino)-propionic acid ethyl ester
• CAS No.: 1013327-66-6
• Molecular Formula: C₁₂H₁₂F₂N₂O₆
• Molecular Weight: 318.234
• Mol file: 1013327-66-6.mol

Synonyms:2,2-difluoro-3-hydroxy-3-(4-nitro-benzoylamino)-propionic acid ethyl ester

Chemical Property of 2,2-difluoro-3-hydroxy-3-(4-nitro-benzoylamino)-propionic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-difluoro-3-hydroxy-3-(4-nitro-benzoylamino)-propionic acid ethyl ester

There total 2 articles about 2,2-difluoro-3-hydroxy-3-(4-nitro-benzoylamino)-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethyl 3-ethoxy-2,2-difluoro-3-hydroxypropionate (141546-97-6) + 4-nitrobenzamide (619-80-7) → 2,2-difluoro-3-hydroxy-3-(4-nitro-benzoylamino)-propionic acid ethyl ester (1013327-66-6)

Guidance literature:

With 5A molecular sieve; In 1,4-dioxane; at 75 ℃; for 240h;

DOI:10.1080/10426500601087418

Reference yield:

ethyl 3-ethoxy-2,2-difluoro-3-(dimethylamino)propionate (141546-96-5) → 2,2-difluoro-3-hydroxy-3-(4-nitro-benzoylamino)-propionic acid ethyl ester (1013327-66-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / Amberlyst 15; H₂O / ethanol

2: 95 percent / molecular sieves 5 Angstroem / dioxane / 240 h / 75 °C

With Amberlyst 15; 5A molecular sieve; water; In 1,4-dioxane; ethanol;

DOI:10.1080/10426500601087418

Reference yield: 35.0%

2,2-difluoro-3-hydroxy-3-(4-nitro-benzoylamino)-propionic acid ethyl ester (1013327-66-6) + trimethylsilyl cyanide (7677-24-9) → 3-cyano-2,2-difluoro-3-(4-nitro-benzoylamino)-propionic acid ethyl ester + 3-cyano-2-fluoro-3-(4-nitro-benzoylamino)-acrylic acid ethyl ester

Guidance literature:

With pyridine; trifluoroacetic anhydride; at 4 ℃; for 0.25h;

DOI:10.1080/10426500601087418

upstream raw materials:

ethyl 3-ethoxy-2,2-difluoro-3-hydroxypropionate

4-nitrobenzamide

ethyl 3-ethoxy-2,2-difluoro-3-(dimethylamino)propionate