4-[5-hydroxy-3-(4-methoxyphenyl)-5-trifluoromethyl-4,5-dihydro-1H-pyrazol-1-yl]-7-chloroquinoline

Base Information

Chemical Name:4-[5-hydroxy-3-(4-methoxyphenyl)-5-trifluoromethyl-4,5-dihydro-1H-pyrazol-1-yl]-7-chloroquinoline
CAS No.:868662-46-8
Molecular Formula:C₂₀H₁₅ClF₃N₃O₂
Molecular Weight:421.806
Hs Code.:

Synonyms:4-[5-hydroxy-3-(4-methoxyphenyl)-5-trifluoromethyl-4,5-dihydro-1H-pyrazol-1-yl]-7-chloroquinoline

Suppliers and Price of 4-[5-hydroxy-3-(4-methoxyphenyl)-5-trifluoromethyl-4,5-dihydro-1H-pyrazol-1-yl]-7-chloroquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-[5-hydroxy-3-(4-methoxyphenyl)-5-trifluoromethyl-4,5-dihydro-1H-pyrazol-1-yl]-7-chloroquinoline

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-[5-hydroxy-3-(4-methoxyphenyl)-5-trifluoromethyl-4,5-dihydro-1H-pyrazol-1-yl]-7-chloroquinoline

There total 4 articles about 4-[5-hydroxy-3-(4-methoxyphenyl)-5-trifluoromethyl-4,5-dihydro-1H-pyrazol-1-yl]-7-chloroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: (E)-1,1,1-Trifluoro-4-methoxy-4-(4-methoxy-phenyl)-but-3-en-2-one

: 23834-14-2
7-chloro-4-hydrazinoquinoline

: 868662-46-8
4-[5-hydroxy-3-(4-methoxyphenyl)-5-trifluoromethyl-4,5-dihydro-1H-pyrazol-1-yl]-7-chloroquinoline

Guidance literature:: In methanol; at 64 ℃;
DOI:10.1002/jhet.5570420604

Reference yield:

: 27150-99-8
1,1-dimethoxy-1-(4-methoxyphenyl)ethane

: 868662-46-8
4-[5-hydroxy-3-(4-methoxyphenyl)-5-trifluoromethyl-4,5-dihydro-1H-pyrazol-1-yl]-7-chloroquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / CHCl₃ / 16 h / 0 - 45 °C

2: methanol / Heating

With pyridine; In methanol; chloroform;
DOI:10.1016/j.bmcl.2005.10.033

Reference yield:

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 868662-46-8
4-[5-hydroxy-3-(4-methoxyphenyl)-5-trifluoromethyl-4,5-dihydro-1H-pyrazol-1-yl]-7-chloroquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: TsOH / methanol / 24 h / 20 °C

2: pyridine / CHCl₃ / 16 h / 0 - 45 °C

3: methanol / Heating

With pyridine; toluene-4-sulfonic acid; In methanol; chloroform;
DOI:10.1016/j.bmcl.2005.10.033