3-(2-fluoro-ethoxy)-4-methanesulfonyl-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide

Base Information

Chemical Name:3-(2-fluoro-ethoxy)-4-methanesulfonyl-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
CAS No.:1079880-48-0
Molecular Formula:C₂₆H₂₄FN₅O₄S
Molecular Weight:521.572
Hs Code.:

Synonyms:3-(2-fluoro-ethoxy)-4-methanesulfonyl-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide

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Chemical Property of 3-(2-fluoro-ethoxy)-4-methanesulfonyl-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide

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Technology Process of 3-(2-fluoro-ethoxy)-4-methanesulfonyl-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide

There total 6 articles about 3-(2-fluoro-ethoxy)-4-methanesulfonyl-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 762-49-2
2-fluoroethyl bromide

: 1079880-99-1
C₂₄H₂₁N₅O₄S

: 1079880-48-0
3-(2-fluoro-ethoxy)-4-methanesulfonyl-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide

Guidance literature:: With cesium bicarbonate; In acetonitrile; at 150 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

: 152460-08-7
1-(2-methyl-5-nitrophenyl)guanidine nitrate

: 1079880-48-0
3-(2-fluoro-ethoxy)-4-methanesulfonyl-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / isopropyl alcohol / 12 h / Heating / reflux

2: hydrogenchloride; tin(ll) chloride / water; ethyl acetate / 1.67 h / 0 - 20 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

4: sodium hydroxide; copper(l) iodide; L-proline / water; dimethyl sulfoxide / 0.42 h / 180 °C / Microwave irradiation

5: cesium bicarbonate / acetonitrile / 0.17 h / 150 °C / Microwave irradiation

With hydrogenchloride; sodium hydroxide; copper(l) iodide; cesium bicarbonate; N-ethyl-N,N-diisopropylamine; HATU; L-proline; tin(ll) chloride; In water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

Reference yield:

: 99-55-8
2-methyl-5-nitroaniline

: 1079880-48-0
3-(2-fluoro-ethoxy)-4-methanesulfonyl-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: nitric acid / water; butan-1-ol / 25 h / Heating / reflux

2: sodium hydroxide / isopropyl alcohol / 12 h / Heating / reflux

3: hydrogenchloride; tin(ll) chloride / water; ethyl acetate / 1.67 h / 0 - 20 °C

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

5: sodium hydroxide; copper(l) iodide; L-proline / water; dimethyl sulfoxide / 0.42 h / 180 °C / Microwave irradiation

6: cesium bicarbonate / acetonitrile / 0.17 h / 150 °C / Microwave irradiation

With hydrogenchloride; sodium hydroxide; copper(l) iodide; cesium bicarbonate; nitric acid; N-ethyl-N,N-diisopropylamine; HATU; L-proline; tin(ll) chloride; In water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile; butan-1-ol;