N-(6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxamide

Base Information

Chemical Name:N-(6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxamide
CAS No.:1307812-93-6
Molecular Formula:C₂₂H₁₇F₃N₂O₄
Molecular Weight:430.383
Hs Code.:

Synonyms:N-(6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxamide

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Chemical Property of N-(6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxamide

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Technology Process of N-(6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxamide

There total 7 articles about N-(6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1236188-80-9
3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxylic acid

: 2603-62-5
2-amino-6-methoxy-3,4-dihydronaphthalen-1(2H)-one hydrochloride

: 1307812-93-6
N-(6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxamide

Guidance literature:: 3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃; for 0.416667h;

2-amino-6-methoxy-3,4-dihydronaphthalen-1(2H)-one hydrochloride; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 932-90-1,622-31-1,140461-24-1,140461-25-2,622-32-2
syn-benzaldehyde oxime

: 1307812-93-6
N-(6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

2.1: triethylamine / 1,2-dichloro-ethane / 20 °C

3.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / acetonitrile / 35 °C / sodium phosphate buffer

3.2: 20 °C

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.42 h / 0 - 20 °C

4.2: 2 h / 20 °C

With N-chloro-succinimide; oxalyl dichloride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; triethylamine; N,N-dimethyl-formamide; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 934-16-7
phenylhydroxamoyl chloride

: 1307812-93-6
N-(6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / 1,2-dichloro-ethane / 20 °C

2.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / acetonitrile / 35 °C / sodium phosphate buffer

2.2: 20 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.42 h / 0 - 20 °C

3.2: 2 h / 20 °C

With oxalyl dichloride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; triethylamine; N,N-dimethyl-formamide; In dichloromethane; 1,2-dichloro-ethane; acetonitrile;